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Category: EnzymesarrowKinasesarrowAdenosine Kinase
Cat.No. Product Name
2372 ABT 702 dihydrochloride
Price and Availability

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ABT 702 2HCl
Chemical Name: 5-(3-Bromophenyl)-7-[6-(4-morpholinyl)-3-pyrido[2,3-d]b yrimidin-4-amine dihydrochloride

Biological Activity:

Potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.

Technical Data:

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M.Wt: 536.26
Formula: C22H19N6OBr.2HCl
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in DMSO
Purity: >99%
CAS No: [214697-26-4]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Jarvis et al (2000) ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse. J.Pharmacol.Exp.Ther. 295 1156. Kowaluk et al (2000) ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat. J.Pharmacol.Exp.Ther. 295 1165. Lee et al (2001) Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J.Med.Chem. 44 2133.
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    Keywords: ABT 702 2HCl, Kinases, Adenosine Kinase Inhibitor; Orally Active, ABT702 2HCl, Tocris Bioscience
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