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Neurotensin Receptors

Supporting information

Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the digestive tract and hypothermic and analgesic effects.

NTS1 is distributed widely throughout the brain and gastrointestinal tract, whilst NTS2 is confined to areas of the brain involved in the descending control of nociception, including the periaqueductal gray and dorsal raphe. The human genes encoding NTS1 and NTS2 receptors are located on chromosomes 20q13 and 2p25.1 respectively.

To view external sources of pharmacological information for Neurotensin Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NTS1 Human NTSR1 NM_002531 P30989
Mouse Ntsr1 NM_018766 O88319
Rat Ntsr1 NM_001108967 P20789
NTS2 Human NTSR2 NM_012344 O95665
Mouse Ntsr2 NM_008747 P70310
Rat Ntsr2 NM_022695 Q58I15

Literature for Neurotensin Receptors

Peptide Hormone Receptors Product Listing

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A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
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Peptides Involved in Appetite Modulation Review
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Request copy of Peptides Involved in Appetite Modulation review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Review excerpt: "The appetite-stimulatory circuit expresses orexigenic neurotransmitters which promote appetite, while anorexigenic neurotransmitters released by the inhibitory circuit reduce appetite. In addition to modulation by signals originating in the periphery, these integrative functions are affected by a wide range of neural influences within the brain, reflecting sensory, cognitive, memory and affective processes."

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7-TM Receptor Signaling Poster

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Written by Terry Kenakin et al, this poster highlights the multiple behaviors of seven-transmembrane (7-TM) receptors, including G-protein-dependent and -independent signaling and the concept of collateral efficacy. Compounds available from Tocris are listed.

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Gut Hormones Poster

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Written by Victoria Taylor et al, this poster summarizes the major gut hormones and neuropeptide modulators that influence digestion, appetite and energy expenditure. The intracellular targets of stimulatory and inhibitory hormones and the role of the hypothalamus in signal integration are also described. Compounds available from Tocris are listed.

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Peptide Hormone Receptors Product Listing

Peptide Hormone Receptor Product Listing

Highlights over 200 products for peptide hormone receptors. Request copy or view PDF today.

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Appetite Modulation

Peptides Involved in Appetite Modulation Review

Written by Sonia A. Tucci, Lynsay Kobelis & Tim Kirkham. Request a copy or view PDF today.

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7-TM Receptor Signaling

Written by T. Kenakin et al

7-TM Poster

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

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Gut Hormones and the Regulation of Appetite

Written by V.J. Taylor et al

Gut Hormones Poster

'Gut Hormones and the Regulation of Appetite' summarizes the neuropeptide modulators and gut hormones that influence appetite

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New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

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R&D Symposium 2014

Molecular Mechanisms in Signal Transduction

July 15, 2014

Cambridge, UK