Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the digestive tract and hypothermic and analgesic effects.
NTS1 is distributed widely throughout the brain and gastrointestinal tract, whilst NTS2 is confined to areas of the brain involved in the descending control of nociception, including the periaqueductal gray and dorsal raphe. The human genes encoding NTS1 and NTS2 receptors are located on chromosomes 20q13 and 2p25.1 respectively.View all products for Neurotensin Receptors »
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Literature for Neurotensin Receptors
Peptides Involved in Appetite Modulation Review
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Review excerpt: "The appetite-stimulatory circuit expresses orexigenic neurotransmitters which promote appetite, while anorexigenic neurotransmitters released by the inhibitory circuit reduce appetite. In addition to modulation by signals originating in the periphery, these integrative functions are affected by a wide range of neural influences within the brain, reflecting sensory, cognitive, memory and affective processes."Request copy | Download PDF
7-TM Receptor Signaling Poster
Written by Terry Kenakin et al, this poster highlights the multiple behaviors of seven-transmembrane (7-TM) receptors, including G-protein-dependent and -independent signaling and the concept of collateral efficacy. Compounds available from Tocris are listed.Request copy | View all posters
Gut Hormones Poster
Written by Victoria Taylor et al, this poster summarizes the major gut hormones and neuropeptide modulators that influence digestion, appetite and energy expenditure. The intracellular targets of stimulatory and inhibitory hormones and the role of the hypothalamus in signal integration are also described. Compounds available from Tocris are listed.Request copy | View all posters
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