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Formyl Peptide Receptors
Supporting information
The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower expression levels on endothelial cells, neurons, astrocytes and hepatocytes.
Formyl peptide receptors are involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil chemotaxis and stimulation of the degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been implicated in the pathogenesis of amyloidosis, Alzheimer's disease, prion diseases and HIV. Ligand diversity is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered on chromosome 19q13.3-13.4.
To view external sources of pharmacological information for Formyl Peptide Receptors, please click here: IUPHAR Receptor Code
View all products for Formyl Peptide Receptors »| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| FPR | Human | FPR1 | NM_002029 | P21462 |
| Mouse | Fpr1 | NM_013521 | P33766 | |
| FPR2 | Human | FPR2 | NM_001005738 | P25090 |
| Mouse | Fpr2 | NM_008039 | NP_032065 | |
| FPR3 | Human | FPR3 | NM_002030 | P25089 |
Literature for Formyl Peptide Receptors
7-TM Receptor Signaling Poster
Written by Terry Kenakin et al, this poster highlights the multiple behaviors of seven-transmembrane (7-TM) receptors, including G-protein-dependent and -independent signaling and the concept of collateral efficacy. Compounds available from Tocris are listed.
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7-TM Receptor Signaling
Written by T. Kenakin et al
'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy
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