Mineralocorticoid Receptors
Mineralocorticoid receptors (MRs) are nuclear hormone receptors of the NR3C class, which also includes androgen, progesterone and glucocorticoid receptors. They can exist as homo- or heterodimers and are coupled to Hsp90 or HMGB proteins. The major signaling pathway used by MRs is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-κB, AP-1 or STAT.
- BJP Guide: Mineralocorticoid Receptors
Mineralocorticoid Receptors - More Information
MRs are expressed in epithelial tissues such as the distal nephron and colon, and in non-epithelial tissues such as hippocampal and hypothalamic neurons. Mineralocorticoid receptors are unique in that they have two physiological ligands; aldosterone and cortisol, that act as critical regulators of serum sodium and other electrolytes and cardiovascular tone. The human gene encoding the mineralocorticoid receptor has been localized to 4q31.1.
Mineralocorticoid Receptor Gene Data
| Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| Human | NR3C2 | NM_000901 | P08235 |
| Mouse | Nr3c2 | NM_001083906 | Q8VII8 |
| Rat | Nr3c2 | NM_013131 | P22199 |
Mineralocorticoid Receptor Products
Agonists |
|
Cat.No. |
Product Name / Activity |
| 3685 |
Corticosterone |
| Endogenous glucocorticoid | |
Antagonists |
|
Cat.No. |
Product Name / Activity |
| 3281 | Canrenone |
| Mineralocorticoid receptor antagonist | |
| 2397 | Eplerenone |
| Selective mineralocorticoid receptor antagonist | |
| 2970 | RU 26752 |
| Mineralocorticoid receptor antagonist | |
| 1672 | RU 28318, potassium salt |
| Potent, selective mineralocorticoid receptor antagonist | |
| 2968 | Spironolactone |
| Mineralocorticoid receptor antagonist | |
Related Categories
Buy Now / Print Quote
Find multiple products by catalog number
RSS News Feed
Find out about new products as soon as they go live!
Click on the orange RSS button to read more about our RSS feed and actively opt in.


