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Mineralocorticoid Receptors

Mineralocorticoid receptors (MRs) are nuclear hormone receptors of the NR3C class, which also includes androgen, progesterone and glucocorticoid receptors. They can exist as homo- or heterodimers and are coupled to Hsp90 or HMGB proteins. The major signaling pathway used by MRs is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-κB, AP-1 or STAT.

BJP Guide: Mineralocorticoid Receptors

More Information and Gene Data »

Mineralocorticoid Receptors - More Information

MRs are expressed in epithelial tissues such as the distal nephron and colon, and in non-epithelial tissues such as hippocampal and hypothalamic neurons. Mineralocorticoid receptors are unique in that they have two physiological ligands; aldosterone and cortisol, that act as critical regulators of serum sodium and other electrolytes and cardiovascular tone. The human gene encoding the mineralocorticoid receptor has been localized to 4q31.1.

Mineralocorticoid Receptor Gene Data

Species	Gene Symbol	Gene Accession No.	Protein Accession No.

Human	NR3C2	NM_000901	P08235
Mouse	Nr3c2	NM_001083906	Q8VII8
Rat	Nr3c2	NM_013131	P22199

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Mineralocorticoid Receptor Products

Agonists
Cat.No.	Product Name / Activity
3685	Corticosterone
	Endogenous glucocorticoid
Antagonists
Cat.No.	Product Name / Activity
3934	Benidipine hydrochloride
	Mineralocorticoid receptor antagonist. Also blocks Ca²⁺ channels.
3281	Canrenone
	Mineralocorticoid receptor antagonist
2397	Eplerenone
	Selective mineralocorticoid receptor antagonist
2970	RU 26752
	Mineralocorticoid receptor antagonist
1672	RU 28318, potassium salt
	Potent, selective mineralocorticoid receptor antagonist
2968	Spironolactone
	Mineralocorticoid receptor antagonist