R&D Systems Inc. Tocris Bioscience Boston Biochem

NK1 Receptors

Supporting information

The neurokinin 1 (NK1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum, amygdala and some hypothalamic and thalamic nuclei) and peripheral tissues.

NK1 receptors are thought to mediate central stress reactions, mood control, excitatory neurotransmission, immune modulation and airway and lung function. The receptor displays greater potency for the endogenous agonist substance P than Neurokinin A and Neurokinin B (SP > NKA > NKB). The human gene encoding the NK1 receptor has been localized on chromosome 2 (2p13.1-p12).

To view external sources of pharmacological information for NK1 Receptors, please click here: IUPHAR Receptor Code and BJP Guide

View all products for NK1 Receptors »
Species Gene Symbol Gene Accession No. Protein Accession No.
Human TACR1 NM_001058 P25103
Mouse Tacr1 NM_009313 P30548
Rat Tacr1 NM_012585 P14600

Literature for NK1 Receptors

Pain Research Guide

Request Pain Research Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Request copy | Download PDF

Peptide Hormone Receptors Product Listing

Request Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Request copy | view PDF
Peptides Involved in Appetite Modulation Review
Request or download your copy today
Request copy of Peptides Involved in Appetite Modulation review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Review excerpt: "The appetite-stimulatory circuit expresses orexigenic neurotransmitters which promote appetite, while anorexigenic neurotransmitters released by the inhibitory circuit reduce appetite. In addition to modulation by signals originating in the periphery, these integrative functions are affected by a wide range of neural influences within the brain, reflecting sensory, cognitive, memory and affective processes."

Request copy | Download PDF

Cardiovascular Poster

Request copy of Cardiovascular poster

Written by Janet Maguire and Anthony Davenport, this poster summarizes different GPCR classes of the vascular system and their cognate ligands. The predominant vasoactive response of blood vessels to specific receptor activation is also described. Endogenous ligands and Tocris compounds are listed.

Request copy | View all posters

7-TM Receptor Signaling Poster

Request 7-TM Signaling poster

Written by Terry Kenakin et al, this poster highlights the multiple behaviors of seven-transmembrane (7-TM) receptors, including G-protein-dependent and -independent signaling and the concept of collateral efficacy. Compounds available from Tocris are listed.

Request copy | View all posters

Depression Poster

Request copy of GPCR poster

Written by Phil Skolnick et al, this poster provides an overview of major depressive disorder (MDD), including: potential causes; new and promising targets, both presynaptic and postsynaptic; and the pharmacology of antidepressant drugs. Compounds available from Tocris are listed.

Request copy | View all posters

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Peptide Hormone Receptors Product Listing

Peptide Hormone Receptor Product Listing

Highlights over 200 products for peptide hormone receptors. Request copy or view PDF today.

divider line

Appetite Modulation

Peptides Involved in Appetite Modulation Review

Written by Sonia A. Tucci, Lynsay Kobelis & Tim Kirkham. Request a copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Poster

'Regulation of Vascular Reactivity by G-protein-coupled Receptors' summarizes the key GPCRs regulating vascular reactivity.

divider line

7-TM Receptor Signaling

Written by T. Kenakin et al

7-TM Poster

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

divider line

Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Antidepressants poster

'Antidepressants - Current and Future Targets' provides an overview of the current and future targets for the treatment of major depressive disorder.

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

Bio-Techne Events

Pharmacology 2014

Pharmacology 2014

December 16 - 18, 2014

London, UK

Booth Number: 12