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NK1 Receptors
Supporting information
The neurokinin 1 (NK1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum, amygdala and some hypothalamic and thalamic nuclei) and peripheral tissues.
NK1 receptors are thought to mediate central stress reactions, mood control, excitatory neurotransmission, immune modulation and airway and lung function. The receptor displays greater potency for the endogenous agonist substance P than Neurokinin A and Neurokinin B (SP > NKA > NKB). The human gene encoding the NK1 receptor has been localized on chromosome 2 (2p13.1-p12).
To view external sources of pharmacological information for NK1 Receptors, please click here: IUPHAR Receptor Code and BJP Guide
View all products for NK1 Receptors »| Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| Human | TACR1 | NM_001058 | P25103 |
| Mouse | Tacr1 | NM_009313 | P30548 |
| Rat | Tacr1 | NM_012585 | P14600 |
Literature for NK1 Receptors
Pain Research Guide
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Peptide Hormone Receptors Product Listing
A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:
- Anterior Pituitary Regulation
- Blood Pressure Regulation
- Feeding and Appetite Regulation
- Glucose Regulation
- Peptide Hormone Processing
Peptides Involved in Appetite Modulation Review
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Review excerpt: "The appetite-stimulatory circuit expresses orexigenic neurotransmitters which promote appetite, while anorexigenic neurotransmitters released by the inhibitory circuit reduce appetite. In addition to modulation by signals originating in the periphery, these integrative functions are affected by a wide range of neural influences within the brain, reflecting sensory, cognitive, memory and affective processes."
Request copy | Download PDFCardiovascular Poster
Written by Janet Maguire and Anthony Davenport, this poster summarizes different GPCR classes of the vascular system and their cognate ligands. The predominant vasoactive response of blood vessels to specific receptor activation is also described. Endogenous ligands and Tocris compounds are listed.
Request copy | View all posters7-TM Receptor Signaling Poster
Written by Terry Kenakin et al, this poster highlights the multiple behaviors of seven-transmembrane (7-TM) receptors, including G-protein-dependent and -independent signaling and the concept of collateral efficacy. Compounds available from Tocris are listed.
Request copy | View all postersDepression Poster
Written by Phil Skolnick et al, this poster provides an overview of major depressive disorder (MDD), including: potential causes; new and promising targets, both presynaptic and postsynaptic; and the pharmacology of antidepressant drugs. Compounds available from Tocris are listed.
Request copy | View all postersQuick Order
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Pain Research Product Guide
Highlights over 280 products for Pain research. Request copy or view PDF today.
Peptide Hormone Receptors Product Listing
Highlights over 200 products for peptide hormone receptors. Reserve your free copy today and be amongst the first to receive it.
Appetite Modulation
Written by Sonia A. Tucci, Lynsay Kobelis & Tim Kirkham. Request a copy or view PDF today.
Regulation of Vascular Reactivity by GPCRs
Written by J.J. Maguire and A.P. Davenport
'Regulation of Vascular Reactivity by G-protein-coupled Receptors' summarizes the key GPCRs regulating vascular reactivity.
7-TM Receptor Signaling
Written by T. Kenakin et al
'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy
Antidepressants - Current and Future Targets
Written by P. Skolnich et al
'Antidepressants - Current and Future Targets' provides an overview of the current and future targets for the treatment of major depressive disorder.
Tocris Events
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Federation of European Biochemical Societies Congress 2013
July 6 - 11, 2013
St. Petersburg, Russia
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