Hedgehog Signaling

More Information »The Hedgehog (Hh) signaling pathway is crucial in the development of all animals. In the embryo, it regulates morphogenesis of a variety of tissues and organs; in the adult, it controls stem cell proliferation. There are three known human Hh proteins: Shh, Dhh and Ihh.

Hedgehog Signaling Products

Inhibitors
Cat.No.
Product Name / Activity
1639 AY 9944 dihydrochloride
Inhibitor of Hedgehog (Hh) signaling. Inhibits Δ7-dehydrocholesterol reductase
4838 AZ 12080282 dihydrochloride
Inhibitor of Hedgehog (Hh) signaling
4529 Ciliobrevin A
Hedgehog (Hh) pathway antagonist; inhibits ciliogenesis
1623 Cyclopamine
Inhibitor of Hedgehog (Hh) signaling
3889 GANT 58
GLI1 antagonist; inhibits Hedgehog (Hh) signaling
3191 GANT 61
GLI antagonist; inhibits Hedgehog (Hh) signaling
3839 HPI 1
Inhibits Hedgehog signaling
5554 IHR 1
Potent Smo antagonist
4717 Jervine
Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo
3341 JK 184
Downstream Hedgehog (Hh) signaling pathway inhibitor; inhibits alcohol dehydrogenase 7
4917 M 25
Potent Smoothened (Smo) receptor antagonist
4585 MRT 10
Smoothened (Smo) antagonist
5262 PF 5274857 hydrochloride
High affinity and selective Smoothened (Smo) receptor antagonist
4886 RU-SKI 43 hydrochloride
Hedgehog acyltransferase (Hhat) inhibitor; cell permeable
1974 SANT-1
Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity
3617 SANT-2
Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity
4662 SMANT hydrochloride
Inhibits Smoothened (Smo) accumulation
1638 U 18666A
Inhibitor of Hedgehog (Hh) signaling. Also inhibits cholesterol synthesis
Activators
Cat.No.
Product Name / Activity
4474 20(S)-Hydroxycholesterol
Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation
4366 SAG
Activates the Hedgehog signaling pathway; potent Smoothened receptor agonist
Other
Cat.No.
Product Name / Activity
3267 Thiostrepton
Downregulates FOXM1
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