Lipoxygenase
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific epoxyalcohol compound.
- BJP Guide: Lipoxygenases
Lipoxygenase - More Information
Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1 have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation, growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma, atherosclerosis, osteoporosis and some cancers.
Lipoxygenase Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| 5-LOX | Human | ALOX5 | NM_000698 | P09917 |
| Mouse | Alox5 | NM_009662 | P48999 | |
| Rat | Alox5 | NM_012822 | P12527 | |
| 12R-LOX | Human | ALOX12B | NM_001139 | O75342 |
| Mouse | Alox12b | NM_009659 | O70582 | |
| Rat | Alox12b | NM_001039377 | Q2KMM4 | |
| More Lipoxygenase genes » | ||||
Lipoxygenase Products
Inhibitors |
|
Cat.No. |
Product Name / Activity |
| 1761 | Baicalein |
| 5- and 12-Lipoxygenase inhibitor | |
| 1304 | BW-B 70C |
| 5-Lipoxygenase inhibitor | |
| 1311 | MK 886 |
| Inhibitor of 5-lipoxygenase-activating protein (FLAP) | |
| 2850 | PD 146176 |
| Selective 15-lipoxygenase inhibitor | |
| 2204 | STEARDA |
| Endogenous inhibitor of 5-lipoxygenase | |
| 0645 | 2-TEDC |
| 5-, 12-, 15-Lipoxygenase inhibitor | |
| 3308 | Zileuton |
| Orally active 5-LOX inhibitor | |
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