G Proteins (Heterotrimeric)

More Information »Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an α-, β- and γ-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

G Protein (Heterotrimeric) Products

Inhibitors
Cat.No.	Product Name / Activity
2974	CCG 2046
	Inhibitor of regulator of G-protein signaling 4 (RGS4)
4567	CCG 50014
	Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein
4028	CCG 63802
	Inhibitor of regulator of G-protein signaling 4 (RGS4) protein
3090	Gallein
	Inhibitor of βγ signaling
1931	G-Protein antagonist peptide
	Inhibits G protein activation by GPCRs
3594	GRK2i
	GRK2 inhibitory polypeptide. Gβγ antagonist
4742	Gue 1654
	Selective inhibitor of OXE-R Gβγ signaling
1240	NF 023
	Inhibitor of G_o/iα-subunits; also P2X₁ purinoceptor antagonist
1400	SCH 202676 hydrobromide
	Inhibitor of ligand binding to G-protein-coupled receptors
1884	[D-Trp^7,9,10]-Substance P
	Inhibits M₁ ACh receptor activation of G_q/11
Activators
Cat.No.	Product Name / Activity
1192	Mastoparan
	Activates G_iand G_o
1896	Mastoparan X
	G protein activator peptide
Other
Cat.No.	Product Name / Activity
1089	8-Bromo-cGMP, sodium salt
	cGMP analog; activates PKG
1193	Melittin
	Inhibits G_s and stimulates G_iactivity
3097	Pertussis Toxin
	Catalyzes ADP-ribosylation of G_i, G_o and G_t
1472	Suramin hexasodium salt
	Uncouples G proteins from receptors. Also purinoceptor antagonist