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5-HT Transporters
Supporting information
5-HT transporters (serotonin transporters, SERT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) found widely distributed throughout the brain. They are responsible for re-uptake of 5-HT and undergo a conformational change to move one or more molecules per cycle.
Structural motifs include 12-TM domains, extracellular loops, cytoplasmic C- and N-termini, putative phosphorylation sites acting as potential targets for PKA and PKC and regions essential for 5-HT selective affinity. There is evidence to suggest that SERTs are linked to neuroticism, sexual behavior, alcoholism, clinical depression, hypertension and obsessive-compulsive disorder.
To view external sources of pharmacological information for 5-HT Transporters, please click here: BJP Guide
View all products for 5-HT Transporters »| Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| Human | SLC6A4 | NM_001045 | P31645 |
| Mouse | Slc6a4 | NM_010484 | Q60857 |
| Rat | Slc6a4 | NM_013034 | P31652 |
Literature for 5-HT Transporters
5-HT Receptors Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Review excerpt: "5-hydroxytryptamine...is an ancient biochemical manipulated through evolution to be utilized extensively throughout the animal and plant kingdoms. Mammals employ 5-HT as a neurotransmitter within the central and peripheral nervous systems, and also as a local hormone in numerous other tissues, including the gastrointestinal tract, the cardiovascular system and immune cells."
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5-HT Review
Written by Nicholas Barnes and John Neumaier, leading experts. Request a copy or view PDF today.
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