5-HT Transporters

More Information »5-HT transporters (serotonin transporters, SERT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) found widely distributed throughout the brain. They are responsible for re-uptake of 5-HT and undergo a conformational change to move molecules.

5-HT Transporter Products

Inhibitors
Cat.No.	Product Name / Activity
2341	A 80426 mesylate
	5-HT uptake inhibitor and α₂ antagonist
4456	Amitriptyline hydrochloride
	5-HT and noradrenalin re-uptake inhibitor
4357	Bicifadine hydrochloride
	Noradrenalin, 5-HT and dopamine re-uptake inhibitor
2322	BTS 54-505 hydrochloride
	Potent SNRI; active metabolite of sibutramine (Cat. No. 2290)
1427	Citalopram hydrobromide
	Highly potent and selective 5-HT uptake inhibitor
0457	Clomipramine hydrochloride
	5-HT re-uptake inhibitor
2833	Cocaine hydrochloride
	Inhibitor of monoamine transporters
4358	Dapoxetine hydrochloride
	Selective serotonin reuptake inhibitor
2695	Dexfenfluramine hydrochloride
	5-HT re-uptake inhibitor. Also stimulates 5-HT release
3428	DMT
	SERT inhibitor. Also endogenous σ₁ ligand and 5-HT_2A agonist
4798	(S)-Duloxetine hydrochloride
	Potent 5-HT and NE reuptake inhibitor; also blocks dopamine reuptake
4796	Escitalopram oxalate
	Selective serotonin reuptake inhibitor (SSRI)
0927	Fluoxetine hydrochloride
	5-HT re-uptake inhibitor
1033	Fluvoxamine maleate
	5-HT re-uptake inhibitor
1588	Indatraline hydrochloride
	Potent 5-HT uptake inhibitor. Also inhibits dopamine and noradrenalin uptake
2545	Lofepramine
	5-HT and noradrenalin re-uptake inhibitor (SNRI)
3350	LY 393558
	Dual 5-HT re-uptake inhibitor and 5-HT_1B/1D antagonist
2148	(±)-McN 5652
	Potent, orally active 5-HT uptake inhibitor. Also inhibits noradrenalin and dopamine uptake in vitro
3027	(±)-MDMA hydrochloride
	Inhibitor of 5-HT and dopamine uptake; hallucinogenic
4443	Mephedrone hydrochloride
	Inhibits synaptosomal dopamine and 5-HT uptake
3286	Milnacipran hydrochloride
	5-HT and noradrenalin re-uptake inhibitor (SNRI)
2777	Nefazodone hydrochloride
	5-HT uptake inhibitor and 5-HT_2A antagonist. Antidepressant
2141	Paroxetine maleate
	Highly potent and selective 5-HT uptake inhibitor
2395	Sertraline hydrochloride
	5-HT re-uptake inhibitor
2290	Sibutramine hydrochloride
	5-HT and noradrenalin re-uptake inhibitor (SNRI)
2175	Tetrabenazine
	Potent inhibitor of vesicular monoamine transport; depletes 5-HT stores
2917	Venlafaxine hydrochloride
	Dual serotonin/noradrenalin re-uptake inhibitor
4194	WY 45233 succinate
	Dual serotonin/noradrenalin re-uptake inhibitor
1767	Zimelidine dihydrochloride
	Selective 5-HT uptake inhibitor
Ligand Sets
Cat.No.	Product Name / Activity
1877	Serotonin Uptake Inhibitor Tocriset™
	Selection of 4 serotonin uptake inhibitors (Cat. Nos. 1427, 0457, 0927 and 1033)
Other
Cat.No.	Product Name / Activity
3547	Serotonin hydrochloride
	Endogenous substrate
1972	Tianeptine sodium salt
	Selective facilitator of 5-HT uptake; antidepressant