R&D Systems Inc. Tocris Bioscience Boston Biochem

Protease-Activated Receptors

More Information »Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.

Protease-Activated Receptor Products

Agonists
Cat.No.
Product Name / Activity
3370 AC 264613
PAR2 receptor agonist
3369 AC 55541
Potent and selective PAR2 agonist
1487 AY-NH2
Selective PAR4 agonist
3015 2-Furoyl-LIGRLO-amide
Potent and selective PAR2 agonist
3394 LRGILS-NH2
Control peptide for SLIGRL-NH2 (Cat. No. 1468)
3494 PAR 4 (1-6)
PAR4 peptide fragment; acts as a PAR4 agonist
3393 RLLFT-NH2
Control peptide for TFLLR-NH2 (Cat. No. 1464)
3010 SLIGKV-NH2
PAR2 receptor agonist
1468 SLIGRL-NH2
PAR2-activating peptide
1464 TFLLR-NH2
PAR1-activating peptide
1185 Thrombin Receptor Agonist Peptide
Causes platelet aggregation and secretion
3497 TRAP-6
PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist
3392 VKGILS-NH2
Control peptide for SLIGKV-NH2 (Cat. No. 3010)
Antagonists
Cat.No.
Product Name / Activity
3643 FR 171113
PAR1 antagonist
4751 FSLLRY-NH2
PAR2 peptide antagonist
2614 RWJ 56110
Selective PAR1 antagonist
1592 SCH 79797 dihydrochloride
Potent, selective non-peptide PAR1 antagonist
1488 tcY-NH2
Selective PAR4 antagonist
Modulators
Cat.No.
Product Name / Activity
4755 Q94 hydrochloride
Negative allosteric modulator at PAR1 receptor
Inhibitors
Cat.No.
Product Name / Activity
2511 APC 366
Tryptase inhibitor
1798 Gabexate mesylate
Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin
4570 ML 161
Inhibits PAR1-mediated platelet activation
Other
Cat.No.
Product Name / Activity
3553 Parstatin (human)
Peptide cleaved from PAR1 upon receptor activation
3554 Parstatin (mouse)
Peptide cleaved from PAR1 upon receptor activation

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Cardiovascular Research Product Guide

Cardiovascular Research Guide

Highlights over 250 products for cardiovascular research. Request a copy or view PDF today.

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Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Poster

'Regulation of Vascular Reactivity by G-protein-coupled Receptors' summarizes the key GPCRs regulating vascular reactivity.

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7-TM Receptor Signaling

Written by T. Kenakin et al

7-TM Poster

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

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New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

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