NPY Receptors

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Review excerpt: "The appetite-stimulatory circuit expresses orexigenic neurotransmitters which promote appetite, while anorexigenic neurotransmitters released by the inhibitory circuit reduce appetite. In addition to modulation by signals originating in the periphery, these integrative functions are affected by a wide range of neural influences within the brain, reflecting sensory, cognitive, memory and affective processes."

Written by Janet Maguire and Anthony Davenport, this poster summarizes different GPCR classes of the vascular system and their cognate ligands. The predominant vasoactive response of blood vessels to specific receptor activation is also described. Endogenous ligands and Tocris compounds are listed.

Written by Terry Kenakin et al, this poster highlights the multiple behaviors of seven-transmembrane (7-TM) receptors, including G-protein-dependent and -independent signaling and the concept of collateral efficacy. Compounds available from Tocris are listed.

Written by Victoria Taylor et al, this poster summarizes the major gut hormones and neuropeptide modulators that influence digestion, appetite and energy expenditure. The intracellular targets of stimulatory and inhibitory hormones and the role of the hypothalamus in signal integration are also described. Compounds available from Tocris are listed.