An enzyme is a biological molecule that catalyzes a chemical reaction or causes a chemical change in another substance. The molecules transformed by enzymes are called substrates. Some enzymes act independently but others require the assistance of coenzymes in order to function correctly. Enzymes are generally globular proteins and range from just 62 amino acid residues in size. A small number of RNA-based biological catalysts exist, with the most common being the ribosome; these are referred to as either RNA-enzymes or ribozymes.
Products for Enzymes
An enzyme's name is often derived from its substrate or the chemical reaction it catalyzes. The International Union of Biochemistry and Molecular Biology have developed a nomenclature for enzymes based broadly on the mechanism of action. Each enzyme is described by a sequence of four numbers preceded by "EC".
- EC 1 Oxidoreductases: catalyze oxidation and reduction reactions
- EC 2 Transferases: transfer a functional group (e.g. a methyl or phosphate group)
- EC 3 Hydrolases: catalyze the hydrolysis of various bonds
- EC 4 Lyases: cleave various bonds by means other than hydrolysis and oxidation
- EC 5 Isomerases: catalyze isomerization changes within a single molecule
- EC 6 Ligases: join two molecules with covalent bonds
Regulation and Disease
Enzymes are usually very selective as to which reactions they catalyze and the substrates that are involved in these reactions. This selectivity is extremely important as enzymes serve a wide variety of key functions inside living organisms. They are essential for metabolic function and signal transduction pathways. Tight control of enzyme activity is essential for homeostasis. Malfunction of a single enzyme by mutation, overproduction, underproduction or deletion, can lead to a genetic disease. For example, mutations in genes coding for DNA repair enzymes cause hereditary cancer syndromes such as Xeroderma Pigmentosum. Enzyme inhibitors, substrates and activators are commonly used in the treatment of many diseases, for example, cyclooxygenase inhibitors and the treatment of inflammation.
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Potent, selective LRRK2 inhibitor
Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.