Acetylcholine Muscarinic Receptors

Muscarinic receptors are widely distributed throughout the body and control distinct functions according to location and subtype (M1 - M5).They are predominantly expressed in the parasympathetic nervous system where they exert both inhibitory and excitatory effects.

Acetylcholine Muscarinic Receptor Target Files

Related Categories

Muscarinic receptor agonists and antagonists could prove useful in the research and treatment of a wide range of central nervous system diseases including Alzheimer's disease and Parkinson's disease.

The table below summarizes the properties of muscarinic receptors and includes affinity values of some key muscarinic receptor-selective ligands available from Tocris.

Receptor Subtype M1 M2 M3 M4 M5
Transduction Mechanism ↑PLC (Gq/11) ↓Adenylyl Cyclase (Gi/o) ↑PLC (Gq/11) ↓Adenylyl Cyclase (Gi/o) ↑PLC (Gq/11)
Primary Distribution Neocortex, hippocampus, neostriatum, salivary glands, eye, heart Brain, heart, smooth muscle, salivary glands Smooth muscle, exocrine glands, brain, autonomic ganglia, salivary glands Neostriatum, cortex, hippocampus, autonomic ganglia Substantia nigra, pars compacta, ventral tegmental area, hippocampus
Tissue Function Learning and memory, neuromodulation, M-current inhibition Bradycardia, smooth muscle contraction, antinociception, hyperthermia, ↓ neurotransmitter release (presynaptic) Smooth muscle contraction, gland secretion, ↓ neurotransmitter release (presynaptic) Regulation of dopamine D1 stimulated locomotor activity Unknown

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Guide

Highlights over 250 products for cardiovascular research. Request a copy or view PDF today.

divider line

Learning and Memory

Written by Clea Warburton and Zafar Bashir

Learning and Memory Poster

An overview of the cellular mechanisms underlying recognition memory and its links to long-term depression. Request a copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Poster

'Regulation of Vascular Reactivity by G-protein-coupled Receptors' summarizes the key GPCRs regulating vascular reactivity.

divider line

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Poster

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development.

divider line

The Neurobiology of Alzheimer's Disease

Written by Alan Palmer

Alzheimer's Poster

'The Neurobiology of Alzheimer's Disease' summarizes structural and functional changes observed in the progression of AD.

divider line

New Product Guide


Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

Bio-Techne Events

ECI 2015

4th European Congress on Immunology

September 6 - 9, 2015

Vienna, Austria