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GABAB Receptors
More Information »GABAB receptors are metabotropic G-protein-coupled receptors responsible for mediating the inhibitory effects of GABA alongside ionotropic GABAA and GABAC receptors. They exist as heterodimers of GABAB1 and GABAB2 subunits, with both required for function.
GABAB Receptor Products
Agonists |
|
Cat.No. |
Product Name / Activity |
| 3618 | Acamprosate calcium |
| GABA agonist and glutamatergic modulator | |
| 0796 | (R)-Baclofen |
| Selective GABAB agonist. Active enantiomer of (RS)-Baclofen (Cat. No. 0417) | |
| 0417 | (RS)-Baclofen |
| Selective GABAB agonist | |
| 0344 | GABA |
| Endogenous agonist | |
| 3400 | RuBi-GABA |
| Caged GABA; excitable by visible wavelength | |
| 4709 |
RuBi GABA trimethylphosphine
|
| Caged GABA; inhibits neural activity | |
| 0379 | SKF 97541 |
| Extremely potent GABAB agonist | |
Antagonists |
|
Cat.No. |
Product Name / Activity |
| 1245 | CGP 35348 |
| Brain penetrant, selective GABAB antagonist | |
| 3219 | CGP 36216 hydrochloride |
| GABAB antagonist; displays activity at presynaptic receptors | |
| 1247 | CGP 46381 |
| Brain penetrant, selective GABAB antagonist | |
| 1246 | CGP 52432 |
| Potent, selective GABAB antagonist | |
| 1088 | CGP 54626 hydrochloride |
| Potent, selective GABAB antagonist | |
| 1248 | CGP 55845 hydrochloride |
| Potent, selective GABAB antagonist | |
| 0245 | 2-Hydroxysaclofen |
| Selective GABAB antagonist, more potent than saclofen (Cat. No. 0246) | |
| 0178 | Phaclofen |
| Weak, selective GABAB antagonist | |
| 0246 | Saclofen |
| Selective GABAB antagonist | |
| 0984 | SCH 50911 |
| Selective, competitive, orally active GABAB antagonist | |
Modulators |
|
Cat.No. |
Product Name / Activity |
| 3313 | rac BHFF |
| Potent, selective GABAB positive allosteric modulator | |
| 1514 | CGP 13501 |
| Positive modulator at GABAB receptors | |
| 1513 | CGP 7930 |
| Positive modulator at GABAB receptors | |
| 2001 | GS 39783 |
| Positive modulator at GABAB receptors | |
Other |
|
Cat.No. |
Product Name / Activity |
| 1814 | N-ArachidonylGABA |
| Inhibits pain in vivo | |
| 0806 | Gabapentin |
| Anticonvulsant. Increases brain GABA | |
| 0538 | trans-4-Hydroxycrotonic acid |
| GHB receptor ligand | |
| 0386 | 3-Methyl-GABA |
| Activator of GABA amino-transferase | |
| 1811 | Modafinil |
| Psychostimulant | |
| 0780 | NCS-382 |
| Antagonist of γ-hydroxybutyric acid | |
| 4579 | Pentobarbital sodium salt |
| Enhances GABAergic activity | |
| 2687 | Pentylenetetrazole |
| CNS stimulant | |
| 4578 | Phenobarbital sodium salt |
| Enhances GABAergic activity | |
| 2815 | Valproic acid, sodium salt |
| Increases GABA levels; anticonvulsant | |
| 0808 | Vigabatrin |
| GABA-T inhibitor | |
| 2625 | Zonisamide |
| Anticonvulsant, modulates GABA neurotransmission | |
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