GABAA and GABAC Receptors
GABAA and GABAC receptors are the two ligand-gated ion channels, which, along with the 7-TM GABAB receptor, are responsible for mediating the inhibitory effects of GABA. They are Cys-loop family ion channels that form a pentameric intrinsic anion channel. In mammals, 6α, 3β, 3γ, 1δ, 3ρ, 1ε, 1π and 1θ subunits have been identified. GABAA receptors contain mainly the α-, β- and γ-subunits, whilst GABAC receptors, which are in fact a subtype of GABAA receptors, are formed exclusively from ρ subunits.
GABAA and GABAC Receptor Target Files
A variety of proteins associate with the large intracellular M3-M4 loop of GABAA and GABAC receptors and influence the trafficking, cell surface expression, internalization and function of the receptors. Furthermore, GABAA receptors have modulatory sites for benzodiazepines, barbiturates, neurosteroids and ethanol.
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October 17-21, 2015