GABA_A and GABA_C Receptors

GABA_A and GABA_C receptors are the two ligand-gated ion channels, which, along with the 7-TM GABA_B receptor, are responsible for mediating the inhibitory effects of GABA. They are Cys-loop family ion channels that form a pentameric intrinsic anion channel. In mammals, 6α, 3β, 3γ, 1δ, 3ρ, 1ε, 1π and 1θ subunits have been identified. GABA_A receptors contain mainly the α-, β- and γ-subunits, whilst GABA_C receptors, which are in fact a subtype of GABA_A receptors, are formed exclusively from ρ subunits.

GABA_A and GABA_C Receptor Target Files

GABA_A Receptors

GABA_C Receptors

Related Categories

GABA_B Receptors GABA Transporters

Miscellaneous GABA

A variety of proteins associate with the large intracellular M3-M4 loop of GABA_A and GABA_C receptors and influence the trafficking, cell surface expression, internalization and function of the receptors. Furthermore, GABA_A receptors have modulatory sites for benzodiazepines, barbiturates, neurosteroids and ethanol.