R&D Systems Inc. Tocris Bioscience Boston Biochem

Kainate Receptors

More Information »Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. They contribute to excitatory postsynaptic currents in many regions of the CNS.

Kainate Receptor Products

Agonists
Cat.No.
Product Name / Activity
1107 ATPA
Selective, potent GluR5 agonist
0269 Domoic acid
Potent, selective kainate agonist
0307 (S)-(-)-5-Iodowillardiine
Highly potent, subtype-selective kainate agonist
0222 Kainic acid
Potent excitant and neurotoxin
2225 MNI caged kainic acid
Caged kainic acid
0903 SYM 2081
Highly selective kainate agonist
Antagonists
Cat.No.
Product Name / Activity
2728 ACET
Potent antagonist of GluR5-containing kainate receptors
0190 CNQX
Potent AMPA/kainate antagonist
1045 CNQX disodium salt
Potent AMPA/kainate antagonist. More water soluble form of Cat. No. 0190
0189 DNQX
Selective non-NMDA antagonist
2312 DNQX disodium salt
Selective non-NMDA antagonist. Water-soluble salt of DNQX (Cat. No. 0189)
0845 Evans Blue tetrasodium salt
AMPA/kainate antagonist
2555 GYKI 53655 hydrochloride
Kainate receptor antagonist; blocks GluK3 receptors
2187 NS 3763
Selective non-competitive kainate antagonist; selective for GLUK5
5032 Talampanel
Non-competitive AMPA/kainate antagonist
3620 Topiramate
GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV
1765 UBP 282
AMPA/kainate antagonist; distinguishes between motoneuron and dorsal root kainate receptors
2078 UBP 296
Selective, potent kainate antagonist; selective for GluR5-containing receptors
1766 UBP 301
Kainate receptor antagonist
2079 UBP 302
Selective, potent kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)
3621 UBP 310
GLUK5 antagonist
2345 ZK 200775
Competitive AMPA/kainate antagonist
Ligand Sets
Cat.No.
Product Name / Activity
1824 Kainate Receptor Tocriset™
Selection of 5 kainate receptor ligands (Cat. Nos. 0222, 1107, 0903, 1045 and 1454)
Other
Cat.No.
Product Name / Activity
1777 Arctigenin
Binds to kainate receptors; neuroprotective. Also inhibits IκBα phosphorylation and MEK1
2207 PDZ1 Domain inhibitor peptide
Disrupts interaction between GluR6 and PSD-95 PDZ1 domain
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