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AMPA Receptors
More Information »AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission and play a role in hippocampal synaptic long-term potentiation and depression.
AMPA Receptor Products
Agonists |
|
Cat.No. |
Product Name / Activity |
| 1074 | (RS)-AMPA hydrobromide |
| Selective AMPA agonist. More water soluble form of (RS)-AMPA (Cat. No. 0169) | |
| 0253 | (R)-AMPA |
| Inactive isomer of (RS)-AMPA (Cat. No. 0169) | |
| 0169 | (RS)-AMPA |
| Selective AMPA agonist | |
| 0254 | (S)-AMPA |
| Selective AMPA agonist. Active isomer of (RS)-AMPA (Cat. No. 0169) | |
| 1673 | Cl-HIBO |
| Subtype-selective AMPA agonist (GluR1 and GluR2) | |
| 1543 | (S)-CPW 399 |
| Subtype-selective weakly desensitizing AMPA agonist | |
| 0306 | (S)-(-)-5-Fluorowillardiine |
| Very potent AMPA agonist | |
| 3840 | NPEC-caged-(S)-AMPA |
| Caged (S)-AMPA | |
| 0188 | L-Quisqualic acid |
| AMPA/group I mGlu agonist | |
Antagonists |
|
Cat.No. |
Product Name / Activity |
| 1082 | CFM-2 |
| Non-competitive AMPA antagonist | |
| 0190 | CNQX |
| Potent AMPA/kainate antagonist | |
| 1045 | CNQX disodium salt |
| Potent AMPA/kainate antagonist. More water soluble form of CNQX (Cat. No. 0190) | |
| 2932 | CP 465022 hydrochloride |
| Selective, non-competitive AMPA antagonist | |
| 0189 | DNQX |
| Selective non-NMDA antagonist | |
| 2312 | DNQX disodium salt |
| Selective non-NMDA antagonist. Water-soluble salt of DNQX (Cat. No. 0189) | |
| 0845 | Evans Blue tetrasodium salt |
| AMPA/kainate antagonist | |
| 3099 | GYKI 47261 dihydrochloride |
| Non-competitive AMPA antagonist | |
| 1454 | GYKI 52466 dihydrochloride |
| Selective non-competitive AMPA antagonist | |
| 2555 | GYKI 53655 hydrochloride |
| Non-competitive AMPA receptor antagonist | |
| 4198 | IEM 1925 dihydrobromide |
| Voltage- and use-dependent open-channel antagonist of AMPA receptors | |
| 2766 | Naspm trihydrochloride |
| Ca2+-permeable AMPA receptor antagonist | |
| 0373 | NBQX |
| Potent AMPA antagonist. More selective than CNQX (Cat. No. 0190) | |
| 1044 | NBQX disodium salt |
| Potent AMPA antagonist. More water soluble form of NBQX (Cat. No. 0373) | |
| 2770 | Philanthotoxin 74 |
| GluR1/2 selective AMPA antagonist | |
| 0961 | SYM 2206 |
| Non-competitive AMPA antagonist | |
| 1765 | UBP 282 |
| AMPA/kainate antagonist; distinguishes between motoneuron and dorsal root kainate receptors | |
| 2701 | YM 90K hydrochloride |
| Selective AMPA antagonist | |
| 2345 | ZK 200775 |
| Competitive AMPA/kainate antagonist | |
Modulators |
|
Cat.No. |
Product Name / Activity |
| 4373 |
CMPDA
|
| Positive allosteric modulator of GluA2 receptors | |
| 2980 | CX 546 |
| AMPA receptor potentiator | |
| 0713 | Cyclothiazide |
| AMPA selective desensitization inhibitor | |
| 2929 | PEPA |
| Allosteric potentiator of AMPA receptor desensitization | |
| 3911 | S 18986 |
| Positive allosteric modulator of AMPA | |
Inhibitors |
|
Cat.No. |
Product Name / Activity |
| 0867 | Aniracetam |
| Desensitization inhibitor (AMPA > kainate) | |
| 1219 | IDRA 21 |
| Inhibits AMPA receptor desensitization | |
| 1600 | pep2-AVKI |
| Peptide inhibitor of GluR2 subunit binding to PICK1 | |
| 1599 | pep2-EVKI |
| Peptide inhibitor of GluR2 subunit binding to PICK1 | |
| 1595 | pep2m |
| Peptide inhibitor of GluR2 subunit binding to NSF. Reduces AMPA currents | |
| 3801 | Pep2m, myristoylated |
| Myristoylated form of pep2m (Cat. No. 1595). Peptide inhibitor of GluR2 subunit binding to NSF | |
| 1597 | pep2-SVKI |
| Peptide inhibitor of GluR2 subunit binding to GRIP, ABP and PICK1. Increases AMPA current amplitude | |
Blockers |
|
Cat.No. |
Product Name / Activity |
| 1636 | IEM 1460 |
| Open-channel blocker of AMPA currents; selective for non-GluR2-containing receptors | |
| 4199 | IEM 1754 dihydrobromide |
| Voltage-dependent, open-channel blocker of AMPA currents | |
Ligand Sets |
|
Cat.No. |
Product Name / Activity |
| 1822 | AMPA Receptor Tocriset™ |
| Selection of 5 AMPA receptor ligands (Cat. Nos. 0254, 0306, 1044, 0713 and 1454) | |
Other |
|
Cat.No. |
Product Name / Activity |
| 1048 | 1-BCP |
| Modulates AMPA-mediated responses | |
| 2334 | D15 |
| Endocytosis blocker, impairs AMPA receptor cycling | |
| 0964 | Diazoxide |
| Blocks desensitization of AMPA receptors | |
| 1602 | Pep1-AGL |
| GluR1 subunit C-terminus peptide analog. Analog of Pep1-TGL (Cat. No. 1601) | |
| 1601 | Pep1-TGL |
| GluR1 subunit C-terminus peptide analog | |
| 1598 | pep2-SVKE |
| Inactive control peptide for pep2-SVKI (Cat. No. 1597) | |
| 1596 | pep4c |
| Inactive control peptide for pep2m (Cat. No. 1595) | |
| 2973 | Piracetam |
| Nootropic; modulates Na+-flux at AMPA receptors | |
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