Contact Us | Register | Login

Pharmacology All Targets 7-TM Receptors Ion Channels Nuclear Receptors Enzyme-Linked Receptors Transporters Enzymes Other Pharmacology Cellular Processes Angiogenesis Apoptosis Cell Cycle Cell Metabolism Cytoskeleton & Motor Proteins ECM & Adhesion Molecules Epigenetics Signal Transduction Stem Cells Signaling Pathways Product Type All Products New Products Small Molecules Peptides Controlled Substances Toxins Caged Compounds Fluorescent Probes Screening Libraries Ligand Sets Other Product Types Research Area Cancer Cardiovascular System Endocrinology Immunology Neuroscience Pain & Inflammation Respiratory System

Inward Rectifier Potassium (K_ir) Channels

More Information »The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (K_ir2.x), the G-protein-activated inward-rectifier channels (K_ir3.x) and the ATP-sensitive channels (K_ir6.x), which combine with sulphonylurea receptors.

Inward Rectifier Potassium (K_ir) Channel Products

Activators
Cat.No.	Product Name / Activity
1377	Cromakalim
	Kir6 (KATP) channel opener
0964	Diazoxide
	Kir6 (KATP) channel opener
1378	Levcromakalim
	Kir6 (KATP) channel opener. Active enantiomer of cromakalim (Cat. No. 1377)
0583	Minoxidil
	Kir6 channel (KATP) opener
2147	Nicorandil
	Kir6 (KATP) channel opener and NO donor
1355	P1075
	Potent Kir6 (KATP) channel opener
2580	Tenidap
	Opener of Kir2.3. Also cyclooxygenase (COX-1) inhibitor
2076	Y-26763
	Kir6 (KATP) channel opener
2077	Y-27152
	Prodrug of Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076); orally active in vivo
0882	ZM 226600
	Kir6 (KATP) channel opener
Blockers
Cat.No.	Product Name / Activity
3590	Gambogic acid
	Kir2.1 channel blocker. Also apoptosis inducer
0911	Glibenclamide
	Kir6 (KATP) channel blocker
2396	Glimepiride
	Kir6 (KATP) channel blocker
4549	ML 133 hydrochloride
	Kir2 channel blocker
4231	Nateglinide
	Kir6 (KATP) blocker; displays high affinity for SUR1/Kir6.2 channels
2095	PNU 37883 hydrochloride
	Vascular Kir6 (KATP) channel blocker
3805	Repaglinide
	Kir6 (KATP) channel blocker
3948	Terfenadine
	KV11.1 (hERG) and Kir6 (KATP) channel blocker. Also H1 antagonist
4339	Tertiapin LQ
	Selective Kir1.1 blocker; derivative of tertiapin-Q (Cat. No. 1316)
1316	Tertiapin-Q
	Selective blocker of inward-rectifier K+ channels
3891	VU 590 dihydrochloride
	Inhibitor of Kir1.1 (ROMK) and Kir7.1
4197	VU 591 hydrochloride
	Selective Kir1.1 (ROMK) inhibitor

Related Categories

© Copyright 2013 Tocris Bioscience. All Rights Reserved | Privacy and Cookie Policy | Site map