Inward Rectifier Potassium (Kir) Channels

More Information »The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.

Inward Rectifier Potassium (Kir) Channel Products

Product Name / Activity
1377 Cromakalim
Kir6 (KATP) channel opener
0964 Diazoxide
Kir6 (KATP) channel opener
1378 Levcromakalim
Kir6 (KATP) channel opener; active enantiomer of cromakalim (Cat. No. 1377)
0583 Minoxidil
Kir6 channel (KATP) opener
5380 ML 297
Selective Kir3.1/3.2 (GIRK1/2) channel activator
2147 Nicorandil
Kir6 (KATP) channel opener and NO donor
1355 P1075
Potent Kir6 (KATP) channel opener
2580 Tenidap
Opener of Kir2.3. Also cyclooxygenase (COX-1) inhibitor
2076 Y-26763
Kir6 (KATP) channel opener
2077 Y-27152
Prodrug of Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076); orally active in vivo
0882 ZM 226600
Kir6 (KATP) channel opener
Product Name / Activity
3590 Gambogic acid
Kir2.1 channel blocker. Also apoptosis inducer
0911 Glibenclamide
Kir6 (KATP) channel blocker
2396 Glimepiride
Kir6 (KATP) channel blocker
4549 ML 133 hydrochloride
Kir2 channel blocker
4231 Nateglinide
Kir6 (KATP) blocker; displays high affinity for SUR1/Kir6.2 channels
2095 PNU 37883 hydrochloride
Vascular Kir6 (KATP) channel blocker
3805 Repaglinide
Kir6 (KATP) channel blocker
0925 SCH 23390 hydrochloride
Kir3 channel blocker; also potent dopamine D1-like antagonist, 5-HT1C agonist and 5-HT2C agonist
3948 Terfenadine
KV11.1 (hERG) and Kir6 (KATP) channel blocker. Also H1 antagonist
4339 Tertiapin LQ
Selective Kir1.1 blocker; derivative of tertiapin-Q (Cat. No. 1316)
1316 Tertiapin-Q
Selective blocker of inward-rectifier K+ channels
3891 VU 590 dihydrochloride
Inhibitor of Kir1.1 (ROMK) and Kir7.1
4197 VU 591 hydrochloride
Selective Kir1.1 (ROMK) inhibitor
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