R&D Systems Inc. Tocris Bioscience Boston Biochem

Histone Deacetylases

Supporting information

Histone deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways.

There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is affected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.

Histone acetylation is upregulated during memory formation but downregulated in numerous neurodegenerative diseases, such as Alzheimer's disease and Huntington's disease. As a result, HDAC inhibitors are also of great interest in neuroscience research.

View all products for Histone Deacetylases »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
HDAC1 Human HDAC1 NM_004964 Q13547
Mouse Hdac1 NM_008228 O09106
Rat Hdac1 NM_001025409 Q4QQW4
HDAC2 Human HDAC2 NM_001527 Q92769
Mouse Hdac2 NM_008229 P70288
Rat Hdac2 NM_053447 Q99PA1
View all Histone Deacetylase Gene Data »

Literature for Histone Deacetylases

Cancer Research Guide

Request Cancer Research Guide

A collection of over 350 products for cancer research, the guide contains modulators of:

  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Cell Death and Drug Resistance
  • Angiogenesis
  • Invasion and Metastasis
Request copy | Download PDF

Epigenetics Research Bulletin

Epigenetics Research Bulletin

Produced by Tocris, the epigenetics research bulletin focuses on mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • BET Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
Download PDF

Depression Poster

Request copy of GPCR poster

Written by Phil Skolnick et al, this poster provides an overview of major depressive disorder (MDD), including: potential causes; new and promising targets, both presynaptic and postsynaptic; and the pharmacology of antidepressant drugs. Compounds available from Tocris are listed.

Request copy | View all posters

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Epigenetics Research Bulletin

Epigenetics Research Bulletin

Includes up to date information and products for epigenetics research. View PDF today.

divider line

Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Antidepressants poster

'Antidepressants - Current and Future Targets' provides an overview of the current and future targets for the treatment of major depressive disorder.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

Tocris Events

Meet your representative

R&D Symposium 2014

Molecular Mechanisms in Signal Transduction

July 15, 2014

Cambridge, UK