Hypoxia Inducible Factors

More Information »Hypoxia Inducible Factors (HIFs) are transcription factors that are activated in response to decreased oxygen availability in the cellular environment. They influence cell metabolism, cell survival and angiogenesis to maintain biological homeostasis.

Hypoxia Inducible Factor Products

Inhibitors
Cat.No.
Product Name / Activity
5582 TAT-cyclo-CLLFVY
Selective HIF-1 dimerization inhibitor
4408 DMOG
Inhibitor of hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH)
5520 Echinomycin
Highly potent and selective HIF-1α inhibitor
4451 IOX 2
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
4324 KC7F2
HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
2954 PX 12
Thioredoxin-1 inhibitor; attenuates expression of HIF-1α
5243 TC-S 7009
High affinity and selective HIF-2α inhibitor
Activators
Cat.No.
Product Name / Activity
4565 ML 228
HIF pathway activator
Other
Cat.No.
Product Name / Activity
4705 Chetomin
Blocks interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300
5764 Deferoxamine mesylate
Hypoxia mimetic; also iron chelator
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