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Sphingosine Kinase

Supporting information

Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. SphK constitutes an important checkpoint in the regulation of circulating levels of ceramide, sphingosine and sphingosine-1-phosphate. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.

Sphingosine kinase is activated in response to pro-growth signals via GPCRs (e.g. acetylcholine muscarinic receptors), small GTPases and tyrosine kinase receptors (e.g. VEGFR and PDGFR). Once activated, sphingosine kinase translocates to the plasma membrane, a process aided by TNFα and PMA.

Due to its role in sphingosine-1-phosphate synthesis, SphK is a target of interest in cancer research.

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Gene	Species	Gene Symbol	Gene Accession No.	Protein Accession No.

SPHK1	Human	SPHK1	NM_001142601	Q9NYA1
	Rat	Sphk1	NM_133386	Q91V26
SPHK2	Human	SPHK2	NM_001204158	Q9NRA0
	Rat	Sphk2	NM_001012066	Q6AYB2

Literature for Sphingosine Kinase

Cancer Research Guide

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