R&D Systems Inc. Tocris Bioscience Boston Biochem

β-catenin

More Information »β-catenin protein is an integral part of the canonical Wnt signaling pathway. Wnt binding to Frizzled (Fz) receptors and LRP co-receptors activates Dishevelled (Dsh) proteins; these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3.

β-catenin Products

Antagonists
Cat.No.
Product Name / Activity
1626 Calphostin C
Antagonist of the Tcf/β-catenin complex. Also PKC inhibitor
Modulators
Cat.No.
Product Name / Activity
4767 WAY 316606 hydrochloride
Secreted frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling
Inhibitors
Cat.No.
Product Name / Activity
4475 Cardionogen 1
Inhibitor of Wnt/β-catenin signaling
4675 CCT 031374 hydrobromide
Inhibits TCF-dependent transcription; lowers β-catenin levels
4344 FH 535
Inhibitor of Wnt/β-catenin signaling
4505 ICG 001
Inhibits TCF/β-catenin-mediated transcription
4299 iCRT 14
Inhibits β-catenin-responsive transcription (CRT)
3533 IWP 2
Inhibitor of Wnt processing and secretion; blocks β-catenin accumulation
3532 endo-IWR 1
Axin stabilizer; promotes β-catenin phosphorylation
3947 exo-IWR 1
Negative control for endo-IWR 1 (Cat. No. 3532)
4514 JW 55
Increases β-catenin degradation; inhibits canonical Wnt signaling
4651 JW 67
Wnt pathway inhibitor; induces degradation of active β-catenin
3534 PNU 74654
β-catenin binder; inhibits Wnt signaling
4254 TAK 715
Inhibitor of Wnt/β-catenin signaling
4855 WIKI4
Tankyrase inhibitor; inhibits Wnt signaling
3748 XAV 939
Stimulates β-catenin degradation; inhibits Wnt signaling
Other
Cat.No.
Product Name / Activity
5148 Wnt-C59
Highly potent Porcn inhibitor; downregulates Wnt/β-catenin target genes
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