β-catenin

More Information »β-catenin protein is an integral part of the canonical Wnt signaling pathway. Wnt binding to Frizzled (Fz) receptors and LRP co-receptors activates Dishevelled (Dsh) proteins; these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3.

β-catenin Products

Inhibitors
Cat.No.	Product Name / Activity
4675	CCT 031374 hydrobromide
	Inhibits TCF-dependent transcription; lowers β-catenin levels
4344	FH 535
	Inhibitor of Wnt/β-catenin signaling
4505	ICG 001
	Inhibits TCF/β-catenin-mediated transcription
4299	iCRT 14
	Inhibits β-catenin-responsive transcription (CRT)
3533	IWP 2
	Inhibitor of Wnt processing and secretion; blocks β-catenin accumulation
3532	endo-IWR 1
	Axin stabilizer; promotes β-catenin phosphorylation
3947	exo-IWR 1
	Negative control for endo-IWR 1 (Cat. No. 3532)
4514	JW 55
	Increases β-catenin degradation; inhibits canonical Wnt signaling
4651	JW 67
	Wnt pathway inhibitor; induces degradation of active β-catenin
3534	PNU 74654
	β-catenin binder; inhibits Wnt signaling
4254	TAK 715
	Inhibitor of Wnt/β-catenin signaling
4855	WIKI4
	Tankyrase inhibitor; inhibits Wnt signaling
3748	XAV 939
	Stimulates β-catenin degradation; inhibits Wnt signaling