NF-κB & IκB

More Information »NF-κB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types. It is involved in the cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immunological response to infections.

NF-κB & IκB Products

Inhibitors
Cat.No.	Product Name / Activity
4547	ACHP
	Selective IKKα and IKKβ inhibitor; blocks NF-κB-DNA binding
4857	Amlexanox
	Inhibitor of TBK1 and IKKε; antiallergic agent
4626	Andrographolide
	Inhibits NFκB; blocks androgen receptor (AR) expression
1777	Arctigenin
	Inhibitor of IκBα phosphorylation. Also inhibits MEK1
1743	Bay 11-7085
	Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
1744	Bay 11-7821
	Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
2743	Caffeic acid phenethyl ester
	Specific inhibitor of NF-κB activation
2509	Cardamonin
	Inhibitor of NF-κB activation; anti-inflammatory
3203	Celastrol
	Inhibits TNF-α-induced NF-κB activation
4246	CID 2858522
	Selectively inhibits PKC-induced NF-κB activation
2637	Gliotoxin
	Immunosuppressant; inhibits NF-κB and cytokine production
4590	Honokiol
	Blocks NF-κB activation. Displays anti-inflammatory and antioxidant properties
2861	HU 211
	NF-κB inhibitor; decreases TNF-α, IL-6 and NO production. Also NMDA antagonist
1532	10Z-Hymenialdisine
	Pan kinase inhibitor; blocks NF-κB activation
2539	IKK 16
	Selective inhibitor of IKK
2611	IMD 0354
	Inhibitor of IKKβ
2874	Luteolin
	Blocks NF-κB activation
1748	MG 132
	Inhibits NF-κB activation; proteasome and calpain inhibitor
4354	ML 130
	Inhibits NOD1-induced NF-κB activation
4238	PF 184
	Potent and selective IKKβ inhibitor
1554	Piceatannol
	Inhibits TNF-induced NF-κB activation
1947	PR 39 (porcine)
	IκBα inhibitor
3731	Pristimerin
	Suppresses NF-κB activation
4045	PSI
	Prevents activation of NF-κB. Also inhibits the proteasome
0727	Pyrrolidinedithiocarbamate ammonium
	Inhibits NF-κB, prevents increase in NOS mRNA
1778	Ro 106-9920
	Inhibitor of NF-κB activation
3318	SC 514
	IKKβ inhibitor; attenuates NF-κB-induced gene expression
4426	Tanshinone IIA
	Inhibits NF-κB and AP-1 DNA binding. Displays antioxidant properties
2559	TPCA-1
	Potent, selective inhibitor of IKKβ
2816	Withaferin A
	Inhibits NF-κB activation
Activators
Cat.No.	Product Name / Activity
3906	Betulinic acid
	Activates NF-κB; antitumor and anti-HIV agent. Also TGR5 agonist