R&D Systems Inc. Tocris Bioscience Boston Biochem

Peptide Receptors

Peptide receptors belong to the B class of G-protein-coupled receptors (GPCRs). This is a large group of several hundred GPCRs that are activated by extracellular protein or peptide ligands. Endogenous peptide receptor ligands bind to the N' terminus and/or the 3 extracellular loops of the receptor. The peptide-receptor binding domains are large, conferring high ligand affinity and specificity. Small molecule drugs however only bind to small 'hot spots' that are essential for GPCR activation.

Peptide receptors represent a large, promising group of pharmacological targets for treating human disease. Consistent with the array of physiological roles of peptide receptors, the range of conditions in which they are dysregulated is vast and includes cardiovascular, endocrine and metabolic disorders.

Products for Peptide Receptors

Angiotensin Receptors Apelin Receptor Bombesin Receptors Bradykinin Receptors Calcitonin and Related Receptors Cholecystokinin Receptors CRF Receptors Endothelin Receptors Formyl Peptide Receptors Galanin Receptors Ghrelin Receptors Glucagon and Related Receptors Gonadotropin-Releasing Hormone Receptors KISS-Derived Peptide (KISS1) Receptors Melanin-concentrating Hormone Receptors Melanocortin (MC) Receptors Motilin Receptor
Neuromedin U Receptors Neuropeptide FF/AF Receptors Neurotensin Receptors NPY Receptors Orexin Receptors Other Peptide Receptors Oxytocin Receptors PACAP Receptors Parathyroid Hormone Receptors Protease-Activated Receptors Sensory Neuron-Specific Receptors Somatostatin (sst) Receptors Tachykinin Receptors Thyrotropin-Releasing Hormone Receptors Urotensin-II Receptor Vasopressin Receptors VIP Receptors

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Appetite Modulation

Peptides Involved in Appetite Modulation Review

Written by Sonia A. Tucci, Lynsay Kobelis & Tim Kirkham. Request a copy or view PDF today.

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7-TM Receptor Signaling

Written by T. Kenakin et al

7-TM Poster

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

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New Product Guide

NPG

Highlights over 130 new products added in 2012. Request a copy or view PDF today.

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20% Discount*

Potent, selective LRRK2 inhibitor

Potent LRRK2 inhibitor now available from Tocris Bioscience

Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.

* Terms & conditions