Cell Adhesion Molecules

Supporting information

Cellular adhesion molecules (CAMs) are a large family of transmembrane proteins that link the cytoskeleton and intracellular signaling cascades with the extracellular environment. Cell adhesion molecules have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer.

There are four major families of cell adhesion molecules:

Immunoglobulin Superfamily (IgSF) CAMs - bind to integrins and members of this family include neural cell adhesion molecule (NCAM) and intracellular adhesion molecule (ICAM).
Selectins - Ca²⁺-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).
Integrins - bind IgSFs and extracellular matrix ligands (e.g. collagen, laminin) and regulate focal adhesion kinase and Src family kinase activity.
Cadherins - Ca²⁺-dependent CAMs that are important in cell-cell junctions. Examples include E-cadherin (endothelial), P-cadherin (placental) and N-cadherin (neural).

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Gene	Species	Gene Symbol	Gene Accession No.	Protein Accession No.

NCAM1	Human	NCAM1	NM_000615	Q59FL7
	Mouse	Ncam1	NM_001081445	P13595
	Rat	Ncam1	NM_031521	Q6LDL9
NCAM2	Human	NCAM2	NM_004540	O15394
	Mouse	Ncam2	NM_010954	O35136
	Rat	Ncam2	NM_203409	Q6RKB2
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Literature for Cell Adhesion Molecules

Cancer Research Guide

A collection of over 350 products for cancer research, the guide contains modulators of:

Receptor Signaling
Cell Cycle and DNA Damage Repair
Cell Death and Drug Resistance
Angiogenesis
Invasion and Metastasis

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Angiogenesis Poster

Written by Yongping Crawford and Napoleone Ferrara, this poster highlights major targets for antiangiogenic therapy, namely tumor- and stromal cell-derived pathways. Intrinsic and acquired resistance are described; antiangiogenic therapies targeting the VEGF pathway are also summarized. Compounds available from Tocris are listed.

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