Cell Cycle Inhibitors

Cell cycle inhibitors slow or stop cell cycle progression through various mechanisms. Cell cycle arrest can be induced at different stages, decreasing the rate of cell division and the number of actively cycling cells.

Cell Cycle Inhibitor Products


Cat.No.	Product Name / Activity
4138	ABT 751
	Inhibitor of microtubule polymerization; blocks cell cycle at G₂M
3968	AZD 5438
	Blocks cell cycling at G₂-M, S and G₁ phases
1761	Baicalein
	Induces G₁ and G₂ cell cycle arrest. Also lipoxygenase inhibitor
4436	8-Chloroadenosine
	Cytotoxic nucleoside analog; induces G₂/M arrest
2039	CI 898 trihydrochloride
	Antineoplastic agent; affects G₁/S phase progression
1417	Daidzein
	Arrests cell cycle in G₁ phase
4502	DIM
	Activates Chk2; induces G₂/M cell cycle arrest
3502	Epothilone B
	Microtubule stabilization agent; promotes G₂-M cell cycle arrest
1813	Indirubin-3'-oxime
	Induces cell cycle arrest, antiproliferative
1230	Methotrexate
	Cytotoxic agent
3715	Narciclasine
	Antiproliferative agent; slows cell cycle progression
4761	Plumbagin
	Induces G₂/M cell cycle arrest; anticancer
4817	SKPin C1
	Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest
4282	WYE 687 dihydrochloride
	Potent and selective mTOR inhibitor; induces G₁ cell cycle arrest

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Checkpoint Kinases & the DNA Damage Response

Written by Michelle D. Garrett and Ian Collins

A summary of the response of the checkpoint kinase signaling network to DNA damage, including activation of DNA repair, cell-cycle arrest, senescence and apoptosis.