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Inhibitor of Apoptosis
Supporting information
Inhibitors of apoptosis (IAP) are a family of proteins that are the major regulators of apoptosis through their interaction with the various components of the apoptotic signaling cascades. Originally discovered in baculovirus, the human homologs are sometimes described as baculovirus IAP repeat containing (BIRC) proteins.
There are a number of different IAPs including neuronal apoptosis inhibitory protein (NAIP or BIRC1), cellular IAPs (c-IAP-1 and c-IAP-2, or BIRC2 and BIRC3 respectively), X-chromosome linked IAP (XIAP or BIRC4) and survivin (BIRC5). cIAP-1 and 2 function through interaction with TNF receptors and by binding to the mitochondrial protein, SMAC, preventing it binding to XIAP. Thought to be the most potent apoptosis suppressor, XIAP, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several caspases, is up-regulated in a many tumor cell types.
View all products for Inhibitor of Apoptosis »| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| NAIP | Human | NAIP | NM_004536 | Q13075 |
| Mouse | Naip1 | NM_008670 | Q9QWK5 | |
| Rat | Naip2 | XM_226742 | Q8R4U8 | |
| c-IAP-1 | Human | BIRC2 | NM_001166 | Q13490 |
| Mouse | Birc2 | NM_007465 | Q62210 | |
| Rat | Birc2 | NM_021752 | O88642 | |
| View all Inhibitor of Apoptosis Gene Data » | ||||
Literature for Inhibitor of Apoptosis
Cancer Research Guide
A collection of over 350 products for cancer research, the guide contains modulators of:
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Cell Death and Drug Resistance
- Angiogenesis
- Invasion and Metastasis
Programmed Cell Death Poster
Written by Bram van Raam & Guy Salvesen, this poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
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Cancer Research Guide
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Highlights over 350 products for cancer research. Request a copy or view PDF today.
Programmed Cell Death
Written by Bram van Raam and Guy Salvesen
A summary of the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation. Request a copy or view PDF today.
Apoptosis Pathway
Apoptosis is a mechanism of cell death which occurs after sufficient cellular damage. View pathway or download PDF today.
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