Transient Receptor Potential Channels
Transient receptor potential (TRP) channels are a superfamily of cation channels that are currently divided into six families. TRP channels are expressed ubiquitously and are activated by a wide range of stimuli.
Transient Receptor Potential Channel Target Files
TRP subunits assemble into homo- or heterotetramers with varied permeation properties. They are often functionally associated with G-protein-coupled receptors, receptor tyrosine kinases and phospholipase C and are regulated by the multipotent phosphatidylinositol pathway. Since TRPs are intimately linked with intracellular Ca2+ signaling, they are implicated in the control of cell cycle progression, cell migration, apoptosis and epithelial uptake of divalent ions.
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Potent, selective LRRK2 inhibitor
Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.