Epithelial Sodium Channels

More Information »Epithelial sodium channels (ENaCs) are members of the ENaC/Deg (epithelial amiloride-sensitive Na+ channel and degenerin) family of ion channels. They are highly selective Na+ channels that are localized to polarized epithelial cells. ENaCs are responsible for sodium reabsorption in the distal kidney tubule, and transport Na+ across the epithelium. They have similar functions in alveoli and the colon.

Epithelial Sodium Channel Products

Product Name / Activity
0464 Capsazepine
Activator of ENaCδ; also vanilloid receptor antagonist
Product Name / Activity
3380 Benzamil
NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative
3379 Phenamil
Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channels
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