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Calcium Channels
Calcium is a vital signaling molecule that mediates muscle contraction, neurotransmission, gene expression and more. There are two main types of calcium channels; voltage-gated calcium channels, which open in response to changes in membrane potential and ligand-gated calcium channels, such as IP3 receptors, store operated calcium channels and ryanodine receptors, which are activated by ligand binding.
Calcium Channel Target Files
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Multiple diseases are caused by disruption of normal calcium channel function. Inherited calcium channelopathies include nervous system disorders, such as X-linked night blindness and hemiplegic migraine, muscloskeletal disorders, such as hypokalemic periodic paralysis and malignant hyperthermia, and cardiovascular disorders, including ventricular cardiomyopathy and familial polymorphic ventricular tachycardia.
| Channel Type | L | T | N | P | Q | R |
|---|
| Conductance (pS) | 25 | 5-9 | ~ 20 | 9-19 | 16 | - |
| Activation Threshold | High | Low | High | High | High | High |
| Deactivation Rate | Fast | Slow | Fast | Fast | Fast | Fast |
| Inactivation Rate | Slow | Fast | Moderate | Very Slow | Moderate | Fast |
| Permeability | Ba2+ > Ca2+ | Ba2+ = Ca2+ | Ba2+ > Ca2+ | Ba2+ > Ca2+ | Ba2+ > Ca2+ | Ba2+ > Ca2+ |
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Calcium Imbalance and Neuroprotective Targets
Written by E. Besancon et al
'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.
Neurobiology of Parkinson's Disease
Written by A. Schapira
'Neurobiology and Therapeutics of Parkinson's Disease' highlights the neurobiology of Parkinson's disease and summarizes current and novel therapeutic interventions.
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