Signal Transduction
Stem Cells
Signaling Pathways
Product Type
All Products
New Products
Small Molecules
Peptides
Controlled Substances
Toxins
Caged Compounds
Fluorescent Probes
Screening Libraries
Ligand Sets
Other Product Types
Research Area
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
Calcium Channels
Calcium is a vital signaling molecule that mediates muscle contraction, neurotransmission, gene expression and more. There are two main types of calcium channels; voltage-gated calcium channels, which open in response to changes in membrane potential and ligand-gated calcium channels, such as IP3 receptors, store operated calcium channels and ryanodine receptors, which are activated by ligand binding.
Calcium Channel Target Files
Related Categories
Multiple diseases are caused by disruption of normal calcium channel function. Inherited calcium channelopathies include nervous system disorders, such as X-linked night blindness and hemiplegic migraine, muscloskeletal disorders, such as hypokalemic periodic paralysis and malignant hyperthermia, and cardiovascular disorders, including ventricular cardiomyopathy and familial polymorphic ventricular tachycardia.
| Channel Type | L | T | N | P | Q | R |
|---|
| Conductance (pS) | 25 | 5-9 | ~ 20 | 9-19 | 16 | - |
| Activation Threshold | High | Low | High | High | High | High |
| Deactivation Rate | Fast | Slow | Fast | Fast | Fast | Fast |
| Inactivation Rate | Slow | Fast | Moderate | Very Slow | Moderate | Fast |
| Permeability | Ba2+ > Ca2+ | Ba2+ = Ca2+ | Ba2+ > Ca2+ | Ba2+ > Ca2+ | Ba2+ > Ca2+ | Ba2+ > Ca2+ |
Quick Order
Find multiple products by catalog number
Pain Research Guide
Reserve your free copy
Highlights over 280 products for Pain research. Reserve copy
Calcium Imbalance and Neuroprotective Targets
Written by E. Besancon et al
'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.
Neurobiology of Parkinson's Disease
Written by A. Schapira
'Neurobiology and Therapeutics of Parkinson's Disease' highlights the neurobiology of Parkinson's disease and summarizes current and novel therapeutic interventions.
Tocris Events
Meet your representative
The Role of Cytokines and Signaling in Inflammation
October 15, 2013
Bonn, Germany