Signal Transduction
Stem Cells
Signaling Pathways
Product Type
All Products
New Products
Small Molecules
Peptides
Controlled Substances
Toxins
Caged Compounds
Fluorescent Probes
Screening Libraries
Ligand Sets
Other Product Types
Research Area
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
Elastase
Supporting information
Elastases are a group of serine proteases that specifically degrade elastin. Elastin, together with collagen, is a key protein that contributes to the mechanical properties of connective tissue.
There are two types of elastases; pancreatic elastase (E.C. 3.4.21.36) and leukocyte elastase (also known as neutrophil elastase) (E.C. 3.4.21.37). Pancreatic elastase is a digestive enzyme secreted from the pancreatic acinar cells and exists in a complex with α1-antitrypsin. Leukocyte elastase is a cytoplasmic enzyme that modifies the function of natural killer cells, monocytes and granulocytes. It specifically cleaves Val-X, Ala-X, Leu-X or Met-X peptide bonds.
Elastases have a physiological role in processes such as neutrophil migration, phagocytosis and tissue remodeling, and are known to contribute to the pathology of pulmonary emphysema, cystic fibrosis, infections, inflammation and atherosclerosis.
View all products for Elastase »| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| Elastase 1 | Human | ELA1 | NM_001971 | Q9UNI1 |
| Mouse | Ela1 | NM_033612 | NP_291090 | |
| Rat | Ela1 | NM_012552 | P00773 | |
| Elastase 2 | Human | ELA2 | NM_001972 | P08246 |
| Mouse | Ela2 | NM_015779 | Q3UP87 | |
| Rat | Ela2 | NM_001106767 | XP_234883 | |
| View all Elastase Gene Data » | ||||
