DNA Topoisomerases

More Information »Topoisomerases are ubiquitously expressed enzymes that overcome topological problems in genomic DNA, which can result from DNA replication, transcription and repair. Common problems such as knots and tangles are often resolved by topoisomerases.

DNA Topoisomerase Products

Product Name / Activity
4219 Banoxantrone dihydrochloride
Prodrug topoisomerase II inhibitor
1100 Camptothecin
DNA topoisomerase inhibitor
3203 Celastrol
Topoisomerase II inhibitor
2688 CPT 11
DNA topoisomerase I inhibitor; antitumor
3857 Dexrazoxane hydrochloride
Topoisomerase II inhibitor
2252 Doxorubicin hydrochloride
Antitumor antibiotic agent. Inhibits DNA topoisomerase II
3357 Ellipticine
Antitumor and intercalating agent; inhibits DNA topoisomerase II
3260 Epirubicin hydrochloride
Inhibits DNA topoisomerase II
1226 Etoposide
Topoisomerase II inhibitor
3849 Gatifloxacin
Antibiotic; inhibits bacterial type II topoisomerase
1293 β-Lapachone
DNA topoisomerase I inhibitor
4250 Mitoxantrone dihydrochloride
Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent
3135 NU 2058
Topoisomerase II inhibitor. Also inhibits cdk1 and cdk2
2684 SN 38
DNA topoisomerase I inhibitor; antitumor
4562 Topotecan hydrochloride
DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog
3863 Trovafloxacin mesylate
Antibiotic; inhibits bacterial DNA topoisomerase IV and DNA gyrase
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Checkpoint Kinases & the DNA Damage Response

Written by Michelle D. Garrett and Ian Collins

Cell Cycle Life Science Poster

A summary of the response of the checkpoint kinase signaling network to DNA damage, including activation of DNA repair, cell-cycle arrest, senescence and apoptosis. Request copy today.

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