DNA Topoisomerase

More Information »Topoisomerases are ubiquitously expressed enzymes that overcome topological problems in genomic DNA, which can result from DNA replication, transcription and repair. Common problems such as knots and tangles are often resolved by topoisomerases.

DNA Topoisomerase Products

Inhibitors
Cat.No.	Product Name / Activity
4219	Banoxantrone dihydrochloride
	Prodrug topoisomerase II inhibitor
1100	Camptothecin
	DNA topoisomerase inhibitor
3203	Celastrol
	Topoisomerase II inhibitor
2688	CPT 11
	DNA topoisomerase I inhibitor; antitumor
3857	Dexrazoxane hydrochloride
	Topoisomerase II inhibitor
2252	Doxorubicin hydrochloride
	Antitumor antibiotic agent. Inhibits DNA topoisomerase II
3357	Ellipticine
	Antitumor and intercalating agent; inhibits DNA topoisomerase II
3260	Epirubicin hydrochloride
	Inhibits DNA topoisomerase II
1226	Etoposide
	Topoisomerase II inhibitor
3849	Gatifloxacin
	Antibiotic; inhibits bacterial type II topoisomerase
1293	β-Lapachone
	DNA topoisomerase I inhibitor
4250	Mitoxantrone dihydrochloride
	Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent
3135	NU 2058
	Topoisomerase II inhibitor. Also inhibits cdk1 and cdk2
2684	SN 38
	DNA topoisomerase I inhibitor; antitumor
4562	Topotecan hydrochloride
	DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog
3863	Trovafloxacin mesylate
	Antibiotic; inhibits bacterial DNA topoisomerase IV and DNA gyrase

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