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Thyrotropin-Releasing Hormone Receptors
Supporting information
Thyrotropin-releasing hormone (TRH) receptors are Gq/11-protein-coupled receptors that promote thyroid-stimulating hormone (TSH) and prolactin (PRL) release. Two TRH receptor subtypes, TRH1 and TRH2, have been identified in rodents, but only the TRH1 receptor has been found in humans. TRH1 is predominantly expressed in the anterior pituitary gland, but is also found at appreciable levels in the brain, pancreas, testis, adrenals and lymphoid organs. The human gene encoding the TRH1 receptor is located on chromosome 8q23.1.
To view external sources of pharmacological information for Thyrotropin-Releasing Hormone Receptors, please click here: IUPHAR Receptor Code and BJP Guide
View all products for Thyrotropin-Releasing Hormone Receptors »| Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| Human | TRHR | NM_003301 | P34981 |
| Mouse | Trhr | NM_013696 | P21761 |
| Rat | Trhr | NM_013047 | Q01717 |
Literature for Thyrotropin-Releasing Hormone Receptors
7-TM Receptor Signaling Poster
Written by Terry Kenakin et al, this poster highlights the multiple behaviors of seven-transmembrane (7-TM) receptors, including G-protein-dependent and -independent signaling and the concept of collateral efficacy. Compounds available from Tocris are listed.
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7-TM Receptor Signaling
Written by T. Kenakin et al
'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy
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