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Smoothened Receptors

More Information »Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family. Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In the resting state, Smo receptors are bound to patched (Ptc).

Smoothened Receptor Products

Antagonists
Cat.No.	Product Name / Activity
1623	Cyclopamine
	Inhibitor of Hedgehog (Hh) signaling; Smo antagonist
4717	Jervine
	Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo
4585	MRT 10
	Smoothened (Smo) antagonist
1974	SANT-1
	Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity
3617	SANT-2
	Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity
Other
Cat.No.	Product Name / Activity
4662	SMANT hydrochloride
	Inhibits Smoothened (Smo) accumulation

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