R&D Systems Inc. Tocris Bioscience Boston Biochem

Smoothened Receptors

More Information »Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family. Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In the resting state, Smo receptors are bound to patched (Ptc).

Smoothened Receptor Products

Agonists
Cat.No.
Product Name / Activity
4918 GSA 10
Smo receptor agonist
4551 Purmorphamine
Smo receptor agonist
Antagonists
Cat.No.
Product Name / Activity
1623 Cyclopamine
Inhibitor of Hedgehog (Hh) signaling; Smo antagonist
4717 Jervine
Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo
4917 M 25
Potent Smoothened (Smo) receptor antagonist
4585 MRT 10
Smoothened (Smo) antagonist
5262 PF 5274857 hydrochloride
Potent and selective Smoothened (Smo) receptor antagonist
1974 SANT-1
Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity
3617 SANT-2
Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity
Other
Cat.No.
Product Name / Activity
4474 20(S)-Hydroxycholesterol
Allosteric activator of Hedgehog signaling; induces Smo accumulation
4662 SMANT hydrochloride
Inhibits Smoothened (Smo) accumulation
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