Kinases (also known as phosphotransferases) catalyze phosphorylation. They enable the transfer of the chemically labile γ phosphoryl group from ATP or other nucleoside triphosphates to alcohol or amino group acceptors. Acceptors may be small organic molecules (e.g. glucose) or macromolecules (e.g. proteins) and the phosphorylated form of the acceptor may be more or less active than the non-phosphorylated form. Kinases are widely used in signal transduction pathways and control complex cellular functions.
Kinase Target Files
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Potent, selective LRRK2 inhibitor
Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.