CaM Kinase

Supporting information

Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca²⁺. At basal Ca²⁺ levels, CaMKs are maintained in a dormant state through autoinhibition. Increases in Ca²⁺ levels allows calmodulin to relieve this autoinhibition and activate the kinase activity.

There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed ubiquitously. Some subtypes display specific distributions, for example, CaMKIVβ is expressed exclusively in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

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Gene	Species	Gene Symbol	Gene Accession No.	Protein Accession No.

CaMKI	Human	CAMK1	NM_003656	Q14012
	Mouse	Camk1	NM_133926	Q91YS8
	Rat	Camk1	NM_134468	Q63450
CaMKIδ	Human	CAMK1D	NM_020397	Q8IU85
CaMKIδ	Mouse	Camk1d	NM_177343	Q8BW96
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