Leukotriene and Related Receptors

More Information »Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Leukotriene and Related Receptor Products

Product Name / Activity
2307 Leukotriene B4
BLT1/BLT2 receptor agonist and potent chemotactic factor
Product Name / Activity
3138 BAY-u 9773
Dual CysLT1 and CysLT2 antagonist
2025 Cinalukast
Potent, selective CysLT1 (LTD4) antagonist; orally active
2276 FPL 55712
Leukotriene receptor antagonist
2208 LY 255283
Selective, competitive BLT2 receptor antagonist
2338 MK 571
Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor
3026 ONO 1078
Selective CysLT1 antagonist
1804 SR 2640 hydrochloride
Potent, selective LTD4 /LTE4 receptor antagonist
Product Name / Activity
4742 Gue 1654
Selective inhibitor of OXE-R Gβγ signaling
Product Name / Activity
2756 Arachidonic acid (in Tocrisolve™100)
Endogenous free fatty acid (in water-soluble emulsion)
3541 BAY-X 1005
Orally active 5-lipoxygenase activating protein (FLAP) inhibitor
2709 Cilastatin sodium
Dipeptidase inhibitor; inhibits metabolism of LTD4 to LTE4
1311 MK 886
Inhibitor of 5-lipoxygenase-activating protein (FLAP)
0607 17-ODYA
LTB ω-hydroxylase inhibitor
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