Cannabinoid Receptor Ligands Available from Tocris
Agonists
1120 AM 630
1297 Abn-CBD
CB 2 selective antagonist/inverse agonist
Agonist for putative abnormal-CBD receptor
1319 ACEA
Selection of 3 CB 1 receptor ligands (Cat. Nos. 1319, 1121 and 1117)
Potent, highly selective CB 1 agonist
1318 ACPA
Selection of 5 endogenous cannabinoids (Cat. Nos. 1339, 1298, 1568,
Potent, selective CB 1 agonist
1411 and 1569)
2479 JTE 907
Potent, selective CB 1 agonist (in water-soluble emulsion)
CB 2 -selective antagonist/inverse agonist
1339 Anandamide
2387 LY 320135
Endogenous CB receptor agonist
Selective CB 1 receptor antagonist/inverse agonist
2288 O-1918
Endogenous CB receptor agonist (in water-soluble emulsion)
Silent antagonist for putative abnormal-CBD receptor
1655 O-2050
Endogenous cannabinoid agonist
CB 1 silent antagonist
1354 Arvanil
1569 Virodhamine
Potent CB 1 and TRPV1 agonist/anandamide transport inhibitor
Endogenous CB 1 partial agonist/antagonist. Also CB 2 agonist
2500 Bay 59-3074
2327 WIN 55,212-3
CB 1 /CB 2 receptor partial agonist
CB 2 antagonist/CB 1 partial inverse agonist. Enantiomer of Cat. No.
1038
Selection of 3 CB 1 receptor ligands (Cat. Nos. 1319, 1121 and 1117)
Other
1462
Selection of 5 cannabinoid receptor agonists (Cat. Nos. 1339, 1298,
Inhibits anandamide hydrolysis
0949, 0966 and 1038)
1116
0949 CP 55,940
Anandamide transport inhibitor
Potent CB 1 and CB 2 agonist
1485 DEA
Anandamide transport inhibitor (in water-soluble emulsion)
Endogenous CB 1 agonist
1814 N -ArachidonylGABA
Inhibits pain in vivo
Selection of 5 endogenous cannabinoids (Cat. Nos. 1339, 1298, 1568,
1445 N-arachidonylglycine
1411 and 1569)
Novel endocannabinoid. Suppresses pain in vivo
2374 GW 405833
1383 BML-190
Selective, high affinity CB 2 receptor partial agonist
Potent, selective CB 2 ligand
0966 HU 210
1570 (–)-Cannabidiol
Highly potent cannabinoid agonist
Natural cannabinoid; weak CB 1 antagonist and AMT inhibitor.
1341 JWH 015
Anticonvulsive in vivo
Selective CB 2 agonist
2231 Anti-CB 2
1343 JWH 133
Antibody recognising CB 2 receptors
Potent, selective CB 2 agonist
Blocking peptide for Cat. No. 2231
Potent, selective CB 2 agonist (in water-soluble emulsion)
1481 (–)-5´-DMH-CBD
2433 L-759,633
Metabolically stable anandamide transport inhibitor
High affinity, selective CB 2 agonist
2452 LY 2183240
2434 L-759,656
Novel, potent anandamide uptake inhibitor. Inhibits FAAH
Highly selective CB 2 agonist
1421 MAFP
2139 Leelamine
Potent, irreversible anandamide amidase inhibitor
CB 1 agonist
1446 O-2093
Inverse agonist at a non-CB 1 , non-TRPV1 site. Active in vivo
Potent and selective CB 1 agonist
1484 Oleylethanolamide
Anandamide analogue, anorexic agent
Potent and selective CB 1 agonist (in water-soluble emulsion)
1797 OMDM-2
1568 NADA
Potent inhibitor of anandamide uptake
Endogenous CB 1 agonist. Also vanilloid agonist and inhibitor of FAAH
and AMT
Agonist for putative CB 2 -like receptor. FAAH and PAA substrate
1411 Noladin ether
2206 2-Palmitoylglycerol
Endogenous agonist for CB 1
Endogenous lipid; enhances activity of 2-AG
0878 Oleamide
CB 1 receptor agonist
Inhibitor of FAAH
Agonist for putative CB 2 -like receptor. FAAH and PAA substrate
Collection of cannabinoid receptor and related compounds
1569 Virodhamine
1684 Tocrisolve 100
Endogenous CB 2 agonist. Also CB 1 partial agonist/antagonist
Water-soluble emulsion; negative control for Cat. Nos. 1017, 1685,
1038 WIN 55,212-2
1686, 1781, 1782 and 1783
Highly potent cannabinoid agonist
1966 UCM 707
Antagonists
Potent anandamide transport inhibitor
1117
1392 VDM 11
Potent, selective CB 1 antagonist/inverse agonist
Potent, selective anandamide transport inhibitor
1115
Potent, selective CB 1 antagonist/inverse agonist
Potent, selective anandamide transport inhibitor (in water-soluble
emulsion)
Please note, the product names used in this review are assigned according to the nomenclature employed by Tocris in its catalogue and website.
Tocris Reviews No. 27
©2006 Tocris Cookson
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