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Home » Signaling Pathways » p53 Signaling Pathway
Cdk4/6
DNA-PK
14.3.3σ
p53
p53
p53
JNK
Chk2
Cdc2
Cdk2
Chk1
ATM
ATR
Akt
Apoptosis
Proteasomal
Degradation Nitric Oxide Cell Cycle
Arrest Mdm2 Mdm2
Degradation Nitric Oxide Cell Cycle
Arrest Mdm2 Mdm2
p53 signaling plays an important role in the co-ordination of the cellular response to different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest. Inactivation of p53 has been implicated in tumor progression, it is thought that more than half of all cancers may involve p53-inactivating mutations.
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