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New Products
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December 2010
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 mGlu2 antagonist
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2913 | Ro 64-5229
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IC50 = 0.11 μM. Selective, non-competitive antagonist. Inhibits GTPγ35S binding to mGlu2-containing membranes.
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Related Products: DCG IV LY 341495 (RS)-APICA
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Bcl-2 inhibitor
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4038 | TW 37
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Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively. Inhibits the angiogenic potential of endothelial cells in vitro. Induces S-phase arrest and apoptosis in pancreatic cancer cell lines.
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Related Products: HA14-1 Gambogic acid Bax channel blocker
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Selective NOP receptor antagonist
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3573 | SB 612111
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Ki values are 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors respectively. Antagonizes the pronociceptive action of nociceptin (Cat. No. 0910). Blocks hyperalgesia in an inflammatory pain model.
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Related Products: (±)-J 113397 UFP-101 PF 998425
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Modulator of voltage-sensitive Ca2+ channels
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3775 | Pregabalin
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Anticonvulsant and antiepileptic; used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels. Displays anxiolytic-like activity in models of anxiety.
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Related Products: Gabapentin L-Ascorbic acid ω-Conotoxin GVIA
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α4β1 (VLA-4) antagonist
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3900 | TCS 2314
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IC50 = 4.4 nM. Antagonizes very late antigen-4. Blocks the activation of inflammatory cells.
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Related Products: GR 144053 BIO 1211 MNS
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All new products this month
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AC 261066,
Amiodarone,
ANR 94,
AT 56,
ATPγS tetralithium salt,
Boc-MLF,
BRD 7389,
Carbamazepine,
CART (55-102) (human),
CART (55-102) (rat),
Clotrimazole,
Cyclophosphamide,
Docetaxel,
Doxycycline hyclate,
Etifoxine,
Flutamide,
FR 171113,
Hydrocortisone,
L 006235,
Latrunculin A,
Lisuride ,
Mesulergine,
Niclosamide,
PD 118057,
PKC (19-36),
PM 102,
Pregabalin,
PSI,
Puromycin,
Ro 64-5229,
S 24795,
SB 612111,
TCS 2314,
6-Thioguanine,
TW 37,
UBP 310,
VU 0255035,
WWL 70,
WZ 811,
XAC,
YM 202074
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Alzheimer's Poster
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Written by Alan M. Palmer
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'The Neurobiology of Alzheimer's Disease' summarizes structural and functional changes observed in the progression of AD. Request a copy today.
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Tocris Events
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Meet your representative
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American Society for Cell Biology
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Tocris Booth 1214
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December 11-15th, 2010
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Philadelphia, PA
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