Neurochemicals | Signal Transduction Agents | Peptides | Biochemicals
Tocris Bioscience : www.tocris.com
Tocris Bioscience : www.tocris.com High Performance Life Science Reagents
New Products for December 2007
Potent and selective NOP antagonist
J 113397
Inhibits nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test.
NOP Related Products: JTC 801 Trap 101 NNC 63-0532
Potent CXCR2 antagonist
SB 265610
Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.
Chemokine Receptor Related Products: BX 513 SB 225002 RS 102895
GluR1/2 selective AMPA antagonist
Philanthotoxin 74
Subtype-selective AMPA receptor antagonist; inhibits GluR1/2 but not GluR2/3 receptors.
AMPA Related Products: YM 90K ZK 200775 (S)-AMPA
Dual 5-HT/noradrenalin reuptake inhibitor
Venlafaxine
Displays ~ 30-fold higher affinity for SERT than NET (Ki values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behaviour in the forced-swim test in rats.
Related Products: Lofepramine Sibutramine BTS 54-505
Dipeptidyl peptidase IV inhibitor
DPPI 1c
Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.
Other Protease Inhibitors: Cilastatin ZJ 43
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