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New Products
November 2010
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 TRPM8 blocker
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3989 | AMTB
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TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in a rat model (pIC50 = 6.23).
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Related Products: Icilin WS 12 WS 3
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H3 receptor inverse agonist/antagonist
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3743 | BF 2649
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Histamine H3 receptor inverse agonist (EC50 = 1.5 nM) and antagonist (Ki = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brain penetrant.
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Related Products: (R)-(-)-α-Methylhistamine Imetit Proxyfan
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High affinity CB1 antagonist
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3921 | NIDA 41020
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High affinity CB1 receptor antagonist (Ki = 4.1 nM). Exhibits significantly reduced lipophilicity compared to other CB1 antagonists.
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Related Products: AM 251 AM 281 PF 514273
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Inhibitor of P-gp-mediated MDR
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4042 | PSC 833
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P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analogue of cyclosporin A (Cat No. 1101).
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Related Products: Ko 143 Pyrimethamine Reversan
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FFA1 (GPR40) agonist
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3795 | TUG 424
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Agonist of the free fatty acid receptor FFA1 (GPR40) (EC50 = 32 nM). Enhances glucose-stimulated insulin secretion in INS-1E cells at 100 nM.
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Related Products: Icilin WS 12 WS 3
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All new products this month
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a-Amanitin,
AMTB,
API-1,
L-Ascorbic acid,
BF 2649,
CGP 52411,
Exemestane,
GGTI 298,
exo-IWR 1,
LDN 57444,
LG 100754,
Naspm,
NIDA 41020,
1-Oleoyl lysophosphatidic acid sodium salt,
[Glu27]-PKC (19-36),
PSC 833,
S 107,
Tolterodine L-tartrate,
TUG 424,
Tunicamycin,
UK 78282,
Veratridine
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Careers at Tocris
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Tocris Bioscience currently has opportunities for a Marketing Officer.
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We invite your application for this position by Friday, November 5.
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Tocris Events
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Meet your representative
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Society for Neuroscience 2010
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Booth 1536
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November 13-17th, 2010
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San Diego, CA
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Alzheimer's Poster
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Written by Alan M. Palmer
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'The Neurobiology of Alzheimer's Disease' summarizes structural and functional changes observed in the progression of AD. Request a copy or view PDF today.
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Tocris Events
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Meet your representative
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ASCB 2010
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Booth 1214
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December 11-15th, 2010
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Philadelphia, PA
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