New Products for November 2009

Potent and selective CB₁ agonist

3676 | PF 514273

K_i values are 1 and > 10000 nM at CB₁ and CB₂ receptors respectively. Inhibits food intake in vivo following oral administration.

Related Products: AM 251 LY 320135 O-2050

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Selective FGFR1 and -3 inhibitor

3044 | PD 173074

IC₅₀ values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively. Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis.

Related Products: SU 5402 SU 6668

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Selective D₂-like agonist

3680 | Ropinirole

D₃ > D₂ > D₄. Causes biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice. Displays antiParkinsonian activity.

Related Products: (-)-Quinpirole Bromocriptine (S)-(-)-Sulpiride

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Benzodiazepine agonist

3655 | Zaleplon

Non-benzodiazepine agent that acts as an agonist at the benzodiazepine site. Displays hypnotic, anxiolytic, myorelaxant and anticonvulsant activity.

Related Products: L-655,708 Zolpidem Zopiclone

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Dual site Src kinase inhibitor

3642 | Src I1

IC₅₀ values are 44 and 88 nM for Src and Lck respectively. Can be used in parallel with PP 1 and PP 2 to inhibit Src family kinases.

Related Products: Piceatannol PP 2 PP 1

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All new products this month :

Allopregnanolone, BIX 01294, Carcinine, CITCO, GRK2i, (-)-Indolactam V, Lys-γ3-MSH, Neuromedin S (rat), Neuropeptide SF (mouse, rat), N-Nonyldeoxynojirimycin, NXY 059, Parstatin (mouse), PD 173074, 4,4-Pentamethylenepiperidine, PF 514273, Pregnanolone, PRIMA-1MET, Ropinirole, RuBi-4AP, RuBi-Glutamate, Serotonin, Src I1, Zaleplon

Depression Poster

Written by P. Skolnich et al :

'Antidepressants - Current and Future Targets' provides an overview of the current and future targets for the treatment of major depressive disorder.