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New Products
October 2010
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 Positive allosteric modulator of hCaSR
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3815 | R 568
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Allosteric agonist of the human calcium sensing receptor (hCaSR). Restores function to hCaSR mutants. Exerts a suppressive effect on parathyroid (PT) hormone secretion.
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Related Products: Parathyroid hormone (1-34) (human) BAPTA NAADP
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Potent GSK-3β inhibitor
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3869 | TCS 2002
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IC50 = 35 nM. Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain.
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Related Products: TWS 119 BIO-acetoxime BIO
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Potent, selective and reversible CerK inhibitor
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3960 | NVP 231
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IC50 = 12 nM in vitro. Displays selectivity for ceramide kinase (CerK) over sphingosine kinases (IC50 ≥100 μM) and other lipid kinases.
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Related Products: Ceramide Miglustat Fumonisin B1
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Selective H4 receptor antagonist
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4021 | JNJ 7777120
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Ki = 4.5 nM. Displays high affinity and is >1000-fold selective for H4 over other histamine receptors.
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Related Products: 4-Methylhistamine Imetit Clobenpropit
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S6K1 inhibitor
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4032 | PF 4708671
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IC50 = 160 nM. Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1. Displays no effect on the activity of RSK and MSK in vivo.
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Related Products: SL 0101-1 PNU 109291 Rapamycin
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All new products this month
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CHM 1,
CK 666,
(R)-CR8,
16,16-Dimethyl Prostaglandin E2,
DPNI-Caged GABA,
EC 23,
GANT 61,
JNJ 7777120,
LG 100754,
LY 395756,
Minocycline,
MK 217,
MNI caged kainic acid,
Neurodazine,
NPEC-caged-(1S,3R)-ACPD,
NPEC-caged-(S)-3,4-DCPG,
NPEC-caged-dopamine,
NPEC-caged-LY 379268,
NPEC-caged-noradrenalin,
NPEC-caged-serotonin,
NU 6140,
NVP 231,
PF 4708671,
QS 11,
R 568,
S26948,
Tazarotene,
TCS 1105,
TCS 2002
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