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New Products
September 2010
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 Dynamin inhibitor
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3982 | Mdivi 1
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IC50 = 1 - 10 μM. Attenuates Dnm1- and Drp1-mediated mitochondrial division. Also inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis.
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Related Products: Dynasore Dynamin inhibitory peptide NSC 23766
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Hsp70 inhibitor
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3803 | VER 155008
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IC50 = 0.5 μM. Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78; selective against Hsp90β.
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Related Products: Pifithrin-μ Macbecin I 17-AAG
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Positive allosteric modulator of mGlu2
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3949 | CBiPES
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IC50 = 98.2 nM. Mimics the action of LY 379268 (Cat. No. 2453). Attenuates ketamine-evoked histamine release in vivo.
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Related Products: LY 379268 LY 354740 LY 341495
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Potent γ-secretase inhibitor
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2870 | BMS 299897
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IC50 = 12 nM. Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Exhibits no Notch toxicity. Brain penetrant.
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Related Products: Compound W DAPT JLK 6
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α5-selective GABAA inverse agonist
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3817 | MRK 016
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EC50 = 3 nM. Exhibits affinity at benzodiazepine binding site of recombinant human GABAA receptors (Ki values are 0.77 nM, 0.83 nM, 0.85 nM and 1.4 nM for α3-, α1-, α2-, and α5-containing respectively). Increases long-term potentiation (LTP) in mouse hippocampal slices. Exhibits no anxiogenic or proconvulsant activity.
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Related Products: TB 21007 (+)-Bicuculline TCS 1205
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All new products this month
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AS 1949490,
BIO 1211,
BMS 299897,
C 75,
Calcifediol,
CBiPES,
Colivelin,
Cyclofenil,
Daptomycin,
Desformylflustrabromine,
EB 1089,
GANT 58,
HLI 373,
kb NB 142-70,
Kynurenic acid sodium salt,
(RS)-MCPG disodium salt,
Mdivi 1,
MEN 11270,
3-Methyladenine,
MRK 016,
MRS 2693 trisodium salt,
NFAT Inhibitor,
NGD 94-1,
NS 1619,
PG 01,
(±)-PPCC,
SX 011,
VER 155008,
VU 590,
(-)-Xestospongin C,
YM 58483,
YM 750,
Zotepine
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New Product Guide
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Highlights over 250 new products added to the Tocris Bioscience range in 2009/10.
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Tocris News
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Tocris partners with Jena Bioscience
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Jena Bioscience products are now available from Tocris USA. View the Jena range here.
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Special Offer
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25% discount* on selected Tocris products:
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 Selective A1 agonist
Reversible MAGL inhibitor
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*Terms & Conditions
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To view more special offers....
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