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New Products
August 2010
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 Selective inhibitor of TGF-βRI
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3742 | SJN 2511
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IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively. Selective for ALK5 over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 >16 μM). Enhances the efficiency of cellular reprogramming.
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Related Products: SB 431542 A 83-01 SB 525334
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Subtype-selective GABAA receptor agonist
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3941 | TCS 1205
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In vitro Ki values are 14 and 121 nM for GABAA α2 and GABAA α1 respectively. Exhibits non-sedative anxiolytic activity in vivo.
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Related Products: SR 95531 (+)-Bicuculline Muscimol
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D3 antagonist and D2 partial agonist
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3940 | GSK 789472
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pEC50 values are <5.5 and 8.3 for D3 and D2 respectively. Selective against the D4 receptor in both agonist and antagonist assays. Brain penetrant.
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Related Products: (+)-PD 128907 U 99194 GR 103691
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Potent and selective MCH1 antagonist
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3359 | ATC 0065
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IC50 = 15.7 nM. Displays > 96-fold selectivity over MCH2. Exhibits antidepressant and anxiolytic activity in vivo. Also displays affinity for 5-HT1A and 5-HT2B receptors (IC50 values are 62.9 and 266 nM respectively). Orally active.
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Related Products: MCH (human, mouse, rat) ATC 0175 SNAP 94847
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Selective GSK-3 inhibitor
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3966 | AR-A 014418
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IC50 = 104 nM. Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are >100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
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Related Products: SB 216763 SB 415286 BIO-acetoxime
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All new products this month
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AC 264613,
Alexidine,
AR-A 014418,
ATC 0065,
CD 3254,
Deoxynivalenol,
Eeyarestatin I,
FFN511,
FR 180204,
FR 236924,
FTI 276,
FTI 277,
GSK 3787,
GSK 789472,
HQL 79,
Licarbazepine,
LY 311727,
Nalmefene d3,
Neuropeptide Y (scrambled),
NF 340,
PX 12,
Rotigotine,
SCH 221510,
SD 1008,
SJ 172550,
SJN 2511,
TCS 1205,
UVI 3003,
XCT 790,
Zearalenone
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New Product Guide
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Highlights over 250 new products added to the Tocris Bioscience range in 2009/10.
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Asthma Poster
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Written by Peter J. Barnes
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Highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.
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