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High Performance Life Science Reagents |
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New Products for August 2009
Potent and highly selective EP3 antagonist
3342 l L-798,106 Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2 respectively. Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo. Related Products: L-161,982 U 46619 Misoprostol
Orally active, selective 5-HT6 antagonist
3368 l SB 271046 pKi = 9.02 - 8.92. Increases extracellular glutamate and aspartate in the frontal cortex, and exhibits anticonvulsant activity (EC50 = 0.16 μM) and enhances cognition in vivo. Related Products: EMD 386088 SB 399885 SB 258585
SGK inhibitor
3572 l GSK 650394 IC50 values are 62 and 103 nM for SGK1 and SGK2 respectively. Displays > 30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC50 ~ 1 μM). Related Products: Bicalutamide Fluticasone Mifepristone
Potent AMPK activator
3336 l A 769662 EC50 = 0.8 μM. Displays selectivity towards β1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC50 = 3.2 μM) and decreases plasma glucose and triglyceride levels in vivo. Related Products: Dorsomorphin AICAR
GABAA receptor positive allosteric modulator
3597 l Indiplon Ki = 1.2 - 1.7 nM. Acts at the benzodiazepine site. Displays ~ 10-fold selectivity for α1 subunit-containing receptors. Exhibits sedative, hypnotic, anxiolytic and anticonvulsant activity in vivo and is orally active. Related Products: (-)-Bicuculline methochloride L-655,708 SR 95531 All new products this month :A 769662, ACTH (1-39), Adenosine, AZ 11645373, CART (62-76) (rat, human), COG 133, CRSP-1, Cyclosomatostatin, DGAT-1 Inhibitor 4a, DMPO, GSK 650394, HU 211, Indiplon, JKC 363, JWH 018, L-798,106, MCL 0020, γ1-MSH, (-)-Nicotine, NVP DPP 728, (5Z)-7-Oxozeaenol, PIM-1 Inhibitor 2, PNU 177864, SB 271046, SLV 320, Sumatriptan, TAK 165, Topiramate, Tramiprosate, Voglibose, VU 1545 Sign-up for new products e-alerts. |
Kinase Research Guide
Highlights over 220 products for kinase research, including the very latest research tools RSS News FeedFind out about new products as soon as they go live!
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