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New Products
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May 2011
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 Src tyrosine kinase inhibitor
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3963 | AZM 475271
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Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro and in vivo. Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259).
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Related Products: A 419259 PD 166285 1-Naphthyl PP1
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Monoacylglycerol lipase (MAGL) inhibitor
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3836 | JZL 184
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Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM). Potentiates depolarization-induced suppression of excitability in cerebellar Purkinje neurons. Exhibits >300-fold selectivity for MAGL over FAAH in vitro.
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Related Products: Pristimerin N-Arachidonyl maleimide GSK 264220A
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Selective MEK inhibitor
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4237 | PD 184352
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Ki = 300 nM in vitro. Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo. Orally active.
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Related Products: PD 0325901 PD 198306 U0126
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Potent and selective IKK-2 inhibitor
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4238 | PF 184
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IC50 = 37 nM. Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress.
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Related Products: SC 514 IMD 0354 IKK 16
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Selective ERK5/BMK1 inhibitor
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4132 | XMD 8-92
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KD values are 80, 190, 600 and 890 nM for BMK1, DCAMKL2, PLK4 and TNK1 respectively. Displays selectivity over 402 diverse kinases. Blocks growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. Blocks tumor cell proliferation and tumor-associated angiogenesis.
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Related Products: TMCB FR 180204 Anti-ERK1
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All new products this month
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4E1RCat,
A 1120,
A 419259,
AA 29504,
ABT 751,
AS 1269574,
AZM 475271,
3-Bromocytisine,
Cl-4AS-1,
CP 945598,
JNJ 10181457,
JZL 184,
LG 101506,
LY 266097,
Nateglinide,
NBI 35965,
PD 184352,
PF 184,
PK 44 phosphate,
Prostaglandin F2α,
SID 26681509,
Sumanirole ,
TCN 213,
TFM-4AS-1,
TMN 355,
Travaprost,
Valsartan,
XCC,
XMD 8-92,
YIL 781
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